不同生物活性玻璃在聚二甲基硅氧烷根管封闭剂中的行为。
Behaviour of different bioactive glasses incorporated in polydimethylsiloxane endodontic sealer.
机构信息
Department of Biomaterials Science and Turku Clinical Biomaterials Centre - TCBC, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, FI-20520 Turku, Finland.
Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Piispankatu 8, 20500 Turku, Finland.
出版信息
Dent Mater. 2021 Feb;37(2):321-327. doi: 10.1016/j.dental.2020.11.013. Epub 2021 Jan 10.
OBJECTIVES
The aim of this study was to analyze the behavior of different bioactive glass fillers (BAGs) embedded in a polydimethylsiloxane matrix of an endodontic sealer.
METHODS
Three different endodontic sealers were fabricated using S53P4, 45S5 and 18-06 glass fillers. Endodontic sealer Guttaflow Bioseal consisting of polydimethylsiloxane (PDMS) matrix was used as base of the experimental sealers. Behaviors of different glass fillers leaching from polymer matrix was studied in vitro for 14 days by measuring static ion dissolution profiles of Si, Na, Ca and P -ions. In addition, pH of the simulated bodyfluid (SBF) was monitored during the 14 days and all the sealer samples was examined with SEM/EDX analysis on the surface. Identical but non-glass filler containing polydimethylsiloxane-based sealer was used as a control material.
RESULTS
By the time point of 24 h sealer with 45S5 had released twice as much of Si-ions compared to sealer with S53P4. No statistical differences of Na, Ca and P -ions dissolution were observed in the first 168 h for any groups whereas concentrations of Ca and P -ions decreased with 45S5 significantly after 336 h. Highest pH was measured for sealers with glass filler 45S5 and S53P4 (7.64-7.65). Visible mineral precipitation was observed only on sealer surfaces after 336 h' time period with groups of 45S5 and S53P4. However, presence of calcium and phosphorus oxides was confirmed only with 45S5.
SIGNIFICANCE
Bioactive glass type 45S5 outperforms S53P4 and 18-06 by acting more dynamically in vitro set-up.
目的
本研究旨在分析不同生物活性玻璃填料（BAG）嵌入牙根管封闭剂聚二甲基硅氧烷（PDMS）基质中的行为。
方法
使用 S53P4、45S5 和 18-06 玻璃填料制备了三种不同的牙根管封闭剂。牙根管封闭剂 Guttaflow Bioseal 由 PDMS 基质组成，用作实验封闭剂的基础。通过测量 Si、Na、Ca 和 P 离子的静态离子溶解曲线，体外研究了不同玻璃填料从聚合物基质中的溶出行为 14 天。此外，在 14 天内监测了模拟体液（SBF）的 pH 值，并用 SEM/EDX 分析对所有密封剂样品进行了表面检查。使用不含玻璃填料的相同 PDMS 基密封剂作为对照材料。
结果
在 24 小时时，45S5 密封剂释放的 Si 离子是 S53P4 密封剂的两倍。在最初的 168 小时内，任何组别的 Na、Ca 和 P 离子溶解均无统计学差异，而在 336 小时后，45S5 组的 Ca 和 P 离子浓度显著下降。含有 45S5 和 S53P4 玻璃填料的密封剂的 pH 值最高（7.64-7.65）。仅在 45S5 和 S53P4 组的 336 小时后观察到可见的矿物质沉淀。然而，仅在 45S5 组中证实存在钙和磷氧化物。
意义
在体外设定中，生物活性玻璃 45S5 的性能优于 S53P4 和 18-06。
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