Panahi Kokhdan Esmaeel, Sadeghi Hossein, Kazemi Shima, Doustimotlagh Amir Hossein
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran.
Evid Based Complement Alternat Med. 2021 Jan 25;2021:8847212. doi: 10.1155/2021/8847212. eCollection 2021.
Cisplatin (Cis) is an anticancer drug; however, it has dose-dependent renal toxicity. The current study aims to investigate the protective effects of Boiss. hydroalcoholic extract (Z.M.B), carvacrol, and thymol on cisplatin-induced nephrotoxicity in rats.
Forty-two Wistar male rats were randomly allocated into six groups ( = 7). Group I received normal saline; group II received Cis (7 mg/kg. ip); group III received the Z.M.B extract only (500 mg/kg/d, po); group IV received Z.M.B extract (500 mg/kg/d, po) + Cis; group V received carvacrol (50 mg/kg/d, po) + Cis; and group VI received thymol (50 mg/kg/d, po) + Cis. The levels of biochemical markers, oxidative stress parameters, and histopathological staining were determined in serum and renal tissues. Also, the chemical compositions (carvacrol and thymol) of the Z.M.B extract were assayed by HPLC analysis.
The results revealed that Z.M.B extract, carvacrol, and thymol markedly decreased the renal index as compared with the Cis-only group. Also, carvacrol and thymol significantly reduced the blood urea nitrogen level as compared with the Cis-only group. Furthermore, Z.M.B extract, carvacrol, and thymol significantly attenuated the Cis-induced increase in malondialdehyde and nitric oxide metabolite. Additionally, histopathological examination showed that Z.M.B extract, carvacrol, and thymol markedly ameliorated Cis-induced renal tubular necrosis.
The results showed renoprotective effects of Z.M.B extract, carvacrol, and thymol in Cis-induced nephrotoxicity in rats. Therefore, Z.M.B extract can be considered as a potential candidate for the protection of nephrotoxicity induced by Cis.
顺铂（Cis）是一种抗癌药物；然而，它具有剂量依赖性肾毒性。本研究旨在探讨布瓦西埃牛至水醇提取物（Z.M.B）、香芹酚和百里香酚对顺铂诱导的大鼠肾毒性的保护作用。
42只雄性Wistar大鼠随机分为6组（每组7只）。第一组给予生理盐水；第二组给予顺铂（7mg/kg，腹腔注射）；第三组仅给予Z.M.B提取物（500mg/kg/d，口服）；第四组给予Z.M.B提取物（500mg/kg/d，口服）+顺铂；第五组给予香芹酚（50mg/kg/d，口服）+顺铂；第六组给予百里香酚（50mg/kg/d，口服）+顺铂。测定血清和肾组织中的生化标志物、氧化应激参数和组织病理学染色。此外，通过高效液相色谱分析测定Z.M.B提取物的化学成分（香芹酚和百里香酚）。
结果显示，与仅给予顺铂的组相比，Z.M.B提取物、香芹酚和百里香酚显著降低了肾指数。此外，与仅给予顺铂的组相比，香芹酚和百里香酚显著降低了血尿素氮水平。此外，Z.M.B提取物、香芹酚和百里香酚显著减轻了顺铂诱导的丙二醛和一氧化氮代谢产物的增加。另外，组织病理学检查表明，Z.M.B提取物、香芹酚和百里香酚显著改善了顺铂诱导的肾小管坏死。
结果表明Z.M.B提取物、香芹酚和百里香酚对顺铂诱导的大鼠肾毒性具有肾保护作用。因此，Z.M.B提取物可被视为保护顺铂诱导的肾毒性的潜在候选物。
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