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2020年东京奥运会开幕式上的新冠病毒风险评估。

COVID-19 risk assessment at the opening ceremony of the Tokyo 2020 Olympic Games.

作者信息

Murakami Michio, Miura Fuminari, Kitajima Masaaki, Fujii Kenkichi, Yasutaka Tetsuo, Iwasaki Yuichi, Ono Kyoko, Shimazu Yuzo, Sorano Sumire, Okuda Tomoaki, Ozaki Akihiko, Katayama Kotoe, Nishikawa Yoshitaka, Kobashi Yurie, Sawano Toyoaki, Abe Toshiki, Saito Masaya M, Tsubokura Masaharu, Naito Wataru, Imoto Seiya

机构信息

Department of Health Risk Communication, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.

Center for Marine Environmental Studies (CMES), Ehime University, 3 Bunkyo, Matsuyama, Ehime, 790-8577, Japan.

出版信息

Microb Risk Anal. 2021 Dec;19:100162. doi: 10.1016/j.mran.2021.100162. Epub 2021 Mar 21.

Abstract

The 2020 Olympic/Paralympic Games have been postponed to 2021, due to the COVID-19 pandemic. We developed a model that integrated source-environment-receptor pathways to evaluate how preventive efforts can reduce the infection risk among spectators at the opening ceremony of Tokyo Olympic Games. We simulated viral loads of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emitted from infectors through talking/coughing/sneezing and modeled temporal environmental behaviors, including virus inactivation and transfer. We performed Monte Carlo simulations to estimate the expected number of newly infected individuals with and without preventive measures, yielding the crude probability of a spectator being an infector among the 60,000 people expected to attend the opening ceremony. Two indicators, i.e., the expected number of newly infected individuals and the newly infected individuals per infector entry, were proposed to demonstrate the extent of achievable infection risk reduction levels by implementing possible preventive measures. A no-prevention scenario produced 1.5-1.7 newly infected individuals per infector entry, whereas a combination of cooperative preventive measures by organizers and the spectators achieved a 99% risk reduction, corresponding to 0.009-0.012 newly infected individuals per infector entry. The expected number of newly infected individuals was calculated as 0.005 for the combination of cooperative preventive scenarios with the crude probability of a spectator being an infector of 1 × 10. Based on our estimates, a combination of cooperative preventions between organizers and spectators is required to prevent a viral spread at the Tokyo Olympic/Paralympic Games. Further, under the assumption that society accepts < 10 newly infected persons traced to events held during the entire Olympic/Paralympic Games, we propose a crude probability of infectors of < 5 × 10 as a benchmark for the suppression of the infection. This is the first study to develop a model that can assess the infection risk among spectators due to exposure pathways at a mass gathering event.

摘要

由于新冠疫情,2020年奥运会/残奥会已推迟至2021年。我们开发了一个整合源-环境-受体途径的模型,以评估预防措施如何降低东京奥运会开幕式观众的感染风险。我们模拟了感染者通过说话/咳嗽/打喷嚏释放的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的病毒载量,并对包括病毒灭活和传播在内的瞬时环境行为进行了建模。我们进行了蒙特卡洛模拟,以估计有无预防措施情况下新感染个体的预期数量,得出了在预计参加开幕式的6万人中一名观众成为感染者的粗略概率。提出了两个指标,即新感染个体的预期数量和每个感染者进入导致的新感染个体数量,以证明通过实施可能的预防措施可实现的感染风险降低程度。无预防措施的情况下,每个感染者进入会产生1.5-1.7名新感染个体,而组织者和观众采取合作预防措施相结合可实现99%的风险降低,即每个感染者进入导致0.009-0.012名新感染个体。对于合作预防情景的组合,新感染个体的预期数量计算为0.005,观众成为感染者的粗略概率为1×10。根据我们的估计,组织者和观众之间需要采取合作预防措施相结合,以防止东京奥运会/残奥会期间病毒传播。此外,假设社会能够接受在整个奥运会/残奥会期间举办的活动中追踪到的新感染人数少于10人,我们提出感染者的粗略概率小于5×10作为抑制感染的基准。这是第一项开发能够评估大规模聚集活动中观众因暴露途径而感染风险的模型的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78a8/7981581/a9e68946f6a5/fx1_lrg.jpg

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