Quiñones-Vico María I, Sanabria-de la Torre Raquel, Sánchez-Díaz Manuel, Sierra-Sánchez Álvaro, Montero-Vílchez Trinidad, Fernández-González Ana, Arias-Santiago Salvador
Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Granada, Spain.
Granada Biosanitary Research Institute (ibs. GRANADA), Granada, Spain.
Front Cell Dev Biol. 2021 Apr 7;9:647012. doi: 10.3389/fcell.2021.647012. eCollection 2021.
The skin is the largest organ of the human body and its main functions include providing protection from external harmful agents, regulating body temperature, and homeostatic maintenance. Skin injuries can damage this important barrier and its functions so research focuses on approaches to accelerate wound healing and treat inflammatory skin diseases. Due to their regenerative and immunomodulatory properties, mesenchymal stromal cells (MSCs) have been reported to play a significant role in skin repair and regeneration. However, it seems that the secretome of these cells and exosomes in particular may be responsible for their functions in skin regeneration and the immunomodulation field. The present review aims to gather the available information about the role of MSC-derived exosomes for both and models of different skin conditions and to highlight the need for further research in order to overcome any limitations for clinical translation.
皮肤是人体最大的器官，其主要功能包括抵御外部有害因素、调节体温和维持内环境稳定。皮肤损伤会破坏这一重要屏障及其功能，因此研究集中在加速伤口愈合和治疗炎症性皮肤病的方法上。由于间充质基质细胞（MSCs）具有再生和免疫调节特性，据报道它们在皮肤修复和再生中发挥着重要作用。然而，这些细胞的分泌组，尤其是外泌体，似乎可能是其在皮肤再生和免疫调节领域发挥功能的原因。本综述旨在收集有关MSC来源的外泌体在不同皮肤状况的体外和体内模型中的作用的现有信息，并强调为克服临床转化的任何限制而进行进一步研究的必要性。
