Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 17671 Athens, Greece.
Department of Nutrition, IASO Hospital, 15123 Athens, Greece.
Int J Environ Res Public Health. 2021 Apr 1;18(7):3700. doi: 10.3390/ijerph18073700.
The Mediterranean diet (MD) has been inversely associated with lung cancer (LC) risk. Hereby we show the preliminary results of our prospective randomised controlled trial in inflammatory and nutritional status of LC patients after 3-month implementation of MD. In total, 30 patients with small-cell or non-small-cell LC (stages III-IV) were enrolled. They were randomly assigned either to Control group, receiving general nutritional guidelines, or the MD group, in which a personalised MD plan was provided. Medical and dietary history, anthropometrics, blood biomarkers, and circulating antioxidant vitamins were assessed. The main outcome was a significantly higher advanced lung cancer inflammation index (ALI) in patients of the control arm than those following MD ( = 0.003). In the MD group, platelets were significantly reduced at the study endpoint ( = 0.044). BMI and body fat mass remained unchanged in both arms, but serum glucose was significantly higher in control compared to MD group ( = 0.017). In conclusion, we showed for the first time that implementing a personalised MD for 3 months is promising to regulate prognostic biomarkers in advanced LC. The final results of our on-going trial will shed a light on the inflammatory, antioxidant and nutritional status of LC patients following MD.
地中海饮食（MD）与肺癌（LC）风险呈负相关。在此，我们展示了我们前瞻性随机对照试验的初步结果，该试验在实施 MD3 个月后，研究了 LC 患者的炎症和营养状况。共有 30 名小细胞或非小细胞 LC（III-IV 期）患者入组。他们被随机分配到对照组，接受一般营养指南，或 MD 组，在 MD 组中提供个性化 MD 计划。评估了医疗和饮食史、人体测量学、血液生物标志物和循环抗氧化维生素。主要结果是对照组患者的晚期肺癌炎症指数（ALI）明显高于 MD 组（=0.003）。在 MD 组中，血小板在研究终点时显著减少（=0.044）。BMI 和体脂肪量在两组中均保持不变，但对照组的血清葡萄糖明显高于 MD 组（=0.017）。总之，我们首次表明，实施个性化 MD 3 个月有望调节晚期 LC 的预后生物标志物。我们正在进行的试验的最终结果将阐明 MD 后 LC 患者的炎症、抗氧化和营养状况。
