LAQV, REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
Des Solutio, Avenida Tenente Valadim, nº 17, 2ºF, 2560-275 Torres Vedras, Portugal.
Molecules. 2021 Apr 17;26(8):2336. doi: 10.3390/molecules26082336.
Recently, deep eutectic systems (DESs) as extraction techniques for bioactive compounds have surfaced as a greener alternative to common organic solvents. In order to study the effect of these systems on the extraction of phenolic compounds from different natural sources, a comprehensive review of the state of the art was carried out. In a first approach, the addition of water to these systems and its effect on DES physicochemical properties such as polarity, viscosity, and acidity was investigated. This review studied the effect of the hydrogen bond donor (HBD) on the nature of the extracted phenolics. The effects of the nature of the HBD, namely carbon chain length as well as the number of hydroxyl, methyl, and carbonyl groups, have shown to play a critical role in the extraction of different phenolic compounds. This review highlights the differences between DES systems and systematizes the results published in the literature, so that a more comprehensive evaluation of the systems can be carried out before any experimental trial.
最近，深共晶溶剂（DESs）作为生物活性化合物的提取技术，作为常见有机溶剂的更绿色替代品而崭露头角。为了研究这些系统对不同天然来源中酚类化合物提取的影响，对该领域的最新技术进行了全面综述。首先，研究了向这些系统中添加水及其对 DES 物理化学性质（如极性、粘度和酸度）的影响。本综述研究了氢键供体（HBD）对提取酚类物质性质的影响。HBD 的性质，即碳链长度以及羟基、甲基和羰基的数量，对不同酚类化合物的提取起着关键作用。本综述强调了 DES 系统之间的差异，并对文献中发表的结果进行了系统整理，以便在进行任何实验之前，可以对系统进行更全面的评估。
