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来自内生真菌的真菌合成银纳米颗粒的功能特性：在生物医学应用中的新意义

Functional Attributes of Myco-Synthesized Silver Nanoparticles from Endophytic Fungi: A New Implication in Biomedical Applications.

作者信息

Seetharaman Prabu Kumar, Chandrasekaran Rajkuberan, Periakaruppan Rajiv, Gnanasekar Sathishkumar, Sivaperumal Sivaramakrishnan, Abd-Elsalam Kamel A, Valis Martin, Kuca Kamil

机构信息

Department of Biotechnology, Bharathidasan University, Tiruchirappalli 620024, India.

Department of Biotechnology, Karpagam Academy of Higher Education, Karpagam University, Coimbatore 641021, India.

出版信息

Biology (Basel). 2021 May 27;10(6):473. doi: 10.3390/biology10060473.

DOI:10.3390/biology10060473
PMID:34071886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8228282/
Abstract

To develop a benign nanomaterial from biogenic sources, we have attempted to formulate and fabricate silver nanoparticles synthesized from the culture filtrate of an endophytic fungus strain LA-1 (PoAgNPs). The synthesized PoAgNPs were exclusively characterized through UV-vis absorption spectroscopy, Fourier Transform Infra-Red spectroscopy (FT-IR), X-ray powder diffraction (XRD), and Transmission Electron Microscopy (TEM) with energy dispersive X-ray spectroscopy (EDX). The synthesized nanoparticles showed strong absorbance around 430 nm with surface plasmon resonance (SPR) and exhibited a face-centered cubic crystalline nature in XRD analysis. Proteins presented in the culture filtrate acted as reducing, capping, and stabilization agents to form PoAgNPs. TEM analysis revealed the generation of polydispersed spherical PoAgNPs with an average size of 52.26 nm. The PoAgNPs showed excellent antibacterial activity against bacterial pathogens. The PoAgNPs induced a dose-dependent cytotoxic activity against human adenocarcinoma breast cancer cell lines (MDA-MB-231), and apoptotic morphological changes were observed by dual staining. Additionally, PoAgNPs demonstrated better larvicidal activity against the larvae of . Moreover, the hemolytic test indicated that the as-synthesized PoAgNPs are a safe and biocompatible nanomaterial with versatile bio-applications.

摘要

为了从生物源开发一种良性纳米材料，我们尝试制备并制造了由内生真菌菌株LA-1的培养滤液合成的银纳米颗粒（PoAgNPs）。通过紫外可见吸收光谱、傅里叶变换红外光谱（FT-IR）、X射线粉末衍射（XRD）以及带有能量色散X射线光谱（EDX）的透射电子显微镜（TEM）对合成的PoAgNPs进行了全面表征。合成的纳米颗粒在430 nm左右表现出强烈的吸收峰，具有表面等离子体共振（SPR），并且在XRD分析中呈现出面心立方晶体性质。培养滤液中存在的蛋白质充当还原剂、封端剂和稳定剂以形成PoAgNPs。TEM分析显示生成了多分散的球形PoAgNPs，平均尺寸为52.26 nm。PoAgNPs对细菌病原体表现出优异的抗菌活性。PoAgNPs对人腺癌乳腺癌细胞系（MDA-MB-231）诱导了剂量依赖性的细胞毒性活性，并通过双重染色观察到凋亡形态变化。此外，PoAgNPs对[此处原文缺失相关蚊虫名称]的幼虫表现出更好的杀幼虫活性。而且，溶血试验表明合成的PoAgNPs是一种安全且生物相容的纳米材料，具有多种生物应用。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/8228282/0249e87af8e1/biology-10-00473-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/8228282/20e1f2b0c752/biology-10-00473-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4000/8228282/7c0fcfbe699f/biology-10-00473-g003.jpg
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