Belete Shiret, Meseret Melke, Dejene Haileyesus, Assefa Ayalew
Department of Veterinary Medicine, Woldia University, Woldia, Ethiopia.
College of Veterinary Medicine, University of Gondar, Gondar, Ethiopia.
One Health Outlook. 2021 Aug 4;3(1):16. doi: 10.1186/s42522-021-00046-7.
Ethiopia accommodates the second largest number of human rabies deaths in Africa. This systematic review and meta-analysis aimed to summarize and pool estimates of dog-mediated rabies status in Ethiopia.
Published researches between 2010 and 2020 were comprehensively searched and the required information was extracted. The prevalence was estimated using the random-effects meta-analysis because higher heterogeneity between studies was expected.
The pooled estimate of rabies was 32% (95% CI: 19-46%), with individual study prevalence estimates ranged from 1 to 78%. Studies were approximately weighted equally with individual weight ranging from 5.19-5.28%. Subgroup analysis indicated that the random pooled prevalence of rabies was 28% (95% CI: 0-81%) in animals and 33% (95% CI: 20-47%) in humans. Furthermore, a subgroup analysis across regions indicated that the pooled prevalence was 78% in Addis Ababa, 46% in Oromia, 40% in Tigray and 5% in Amhara regional states. No single study was reported from the country's eastern and southern parts to be included in this meta-analysis.
The estimated pooled rabies prevalence was found high and showed varying among study regions. Therefore, focusing on mass dog vaccination campaigns and public awareness should be implemented to control the disease.
埃塞俄比亚是非洲人类狂犬病死亡人数第二多的国家。本系统评价和荟萃分析旨在总结和汇总埃塞俄比亚犬传狂犬病状况的估计值。
全面检索了2010年至2020年发表的研究，并提取了所需信息。由于预期研究之间存在较高的异质性，因此使用随机效应荟萃分析来估计患病率。
狂犬病的合并估计患病率为32%（95%置信区间：19 - 46%），个别研究的患病率估计值范围为1%至78%。各项研究的权重大致相等，个体权重范围为5.19 - 5.28%。亚组分析表明，动物狂犬病的随机合并患病率为28%（95%置信区间：0 - 81%），人类为33%（95%置信区间：20 - 47%）。此外，跨地区的亚组分析表明，亚的斯亚贝巴的合并患病率为78%，奥罗米亚为46%，提格雷为40%，阿姆哈拉地区为5%。该国东部和南部地区没有单一研究被纳入本次荟萃分析。
估计的狂犬病合并患病率较高，且各研究地区存在差异。因此，应开展大规模犬类疫苗接种运动并提高公众意识以控制该病。
