• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

大豆富硒肽对环磷酰胺诱导的免疫抑制小鼠的免疫调节作用

Immunomodulatory effects of selenium-enriched peptides from soybean in cyclophosphamide-induced immunosuppressed mice.

作者信息

Zhang Jian, Gao Siwei, Li He, Cao Mengdi, Li Wenhui, Liu Xinqi

机构信息

National Soybean Processing Industry Technology Innovation Center Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food Additives Beijing Technology and Business University Beijing China.

Chinese Academy of Inspection and Quarantine Beijing China.

出版信息

Food Sci Nutr. 2021 Sep 21;9(11):6322-6334. doi: 10.1002/fsn3.2594. eCollection 2021 Nov.

DOI:10.1002/fsn3.2594
PMID:34760262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8565224/
Abstract

In this study, selenium-enriched soybean peptides (<3 kDa, named Se-SPep) was isolated and purified from the selenium-enriched soybean protein (Se-SPro) hydrolysate by ultrafiltration. The in-vivo immunomodulatory effects of Se-SPep were investigated in cyclophosphamide-induced immunosuppressed mice. Se-SPep treatment could alleviate the atrophy of immune organs and weight loss observed in immunosuppressive mice. Besides, Se-SPep administration could dramatically improve total protein, albumin, white blood cell, immunoglobulin (Ig) M, IgG, and IgA levels in blood. Moreover, Se-SPep strongly stimulated interleukin-2 (IL-2), interferon-gamma (IFN-γ), nitric oxide (NO), and cyclic guanosine monophosphate productions by up-regulating mRNA expressions of IL-2, IFN-γ, and inducible NO synthase in spleen tissue. Furthermore, Se-SPep exhibits more effective immunomodulatory activity compared to Se-SPro and SPep. In conclusion, Se-SPep could effectively enhance the immune capacity of immunosuppressive mice. These findings confirm Se-SPep is an effective immunomodulator with potential application in functional foods or dietary supplements.

摘要

在本研究中，通过超滤从富硒大豆蛋白（Se-SPro）水解物中分离纯化出分子量小于3 kDa的富硒大豆肽（命名为Se-SPep）。在环磷酰胺诱导的免疫抑制小鼠中研究了Se-SPep的体内免疫调节作用。Se-SPep处理可减轻免疫抑制小鼠中观察到的免疫器官萎缩和体重减轻。此外，给予Se-SPep可显著提高血液中的总蛋白、白蛋白、白细胞、免疫球蛋白（Ig）M、IgG和IgA水平。此外，Se-SPep通过上调脾脏组织中白细胞介素-2（IL-2）、γ-干扰素（IFN-γ）和诱导型一氧化氮合酶的mRNA表达，强烈刺激IL-2、IFN-γ、一氧化氮（NO）和环磷酸鸟苷的产生。此外，与Se-SPro和SPep相比，Se-SPep表现出更有效的免疫调节活性。总之，Se-SPep可有效增强免疫抑制小鼠的免疫能力。这些发现证实Se-SPep是一种有效的免疫调节剂，在功能性食品或膳食补充剂中具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/42f86315855a/FSN3-9-6322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/b9c093e0465e/FSN3-9-6322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/ffdccc0741c3/FSN3-9-6322-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/0a71aedd3d40/FSN3-9-6322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/3b28c563de66/FSN3-9-6322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/ad333c9e2971/FSN3-9-6322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/42f86315855a/FSN3-9-6322-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/b9c093e0465e/FSN3-9-6322-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/ffdccc0741c3/FSN3-9-6322-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/0a71aedd3d40/FSN3-9-6322-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/3b28c563de66/FSN3-9-6322-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/ad333c9e2971/FSN3-9-6322-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c2b/8565224/42f86315855a/FSN3-9-6322-g001.jpg

相似文献

1
Immunomodulatory effects of selenium-enriched peptides from soybean in cyclophosphamide-induced immunosuppressed mice.大豆富硒肽对环磷酰胺诱导的免疫抑制小鼠的免疫调节作用
Food Sci Nutr. 2021 Sep 21;9(11):6322-6334. doi: 10.1002/fsn3.2594. eCollection 2021 Nov.
2
Selenium-enriched soybean peptides pretreatment attenuates lung injury in mice induced by fine particulate matters (PM2.5) through inhibition of TLR4/NF-κB/IκBα signaling pathway and inflammasome generation.富硒大豆肽预处理通过抑制 TLR4/NF-κB/IκBα 信号通路和炎性小体生成来减轻细颗粒物 (PM2.5) 诱导的小鼠肺损伤。
Food Funct. 2022 Sep 22;13(18):9459-9469. doi: 10.1039/d2fo01585d.
3
Se-enriched G. frondosa polysaccharide protects against immunosuppression in cyclophosphamide-induced mice via MAPKs signal transduction pathway.富硒灵芝多糖通过 MAPKs 信号转导通路对环磷酰胺诱导的免疫抑制小鼠起保护作用。
Carbohydr Polym. 2018 Sep 15;196:445-456. doi: 10.1016/j.carbpol.2018.05.046. Epub 2018 May 17.
4
Immunomodulatory Effects of Chicken Broth and Histidine Dipeptides on the Cyclophosphamide-Induced Immunosuppression Mouse Model.鸡汤和组氨酸二肽对环磷酰胺诱导免疫抑制模型小鼠的免疫调节作用。
Nutrients. 2022 Oct 25;14(21):4491. doi: 10.3390/nu14214491.
5
Identification and Immunomodulatory Effect on Immunosuppressed Mice of Selenium-Enriched Peptides of Egg White.富硒鸡蛋清肽的鉴定及其对免疫抑制小鼠的免疫调节作用。
J Agric Food Chem. 2022 Oct 5;70(39):12663-12671. doi: 10.1021/acs.jafc.2c04659. Epub 2022 Sep 25.
6
Differences in the gut microbiota composition of rats fed with soybean protein and their derived peptides.喂食大豆蛋白及其衍生肽的大鼠肠道微生物群组成的差异。
J Food Sci. 2021 Dec;86(12):5452-5465. doi: 10.1111/1750-3841.15948. Epub 2021 Nov 3.
7
Shrimp peptide hydrolysate modulates the immune response in cyclophosphamide immunosuppressed mice model.虾肽水解物调节环磷酰胺免疫抑制小鼠模型的免疫反应。
J Food Biochem. 2022 Sep;46(9):e14251. doi: 10.1111/jfbc.14251. Epub 2022 May 28.
8
Lactobacillus sakei K040706 evokes immunostimulatory effects on macrophages through TLR 2-mediated activation.清酒乳杆菌K040706通过Toll样受体2介导的激活对巨噬细胞产生免疫刺激作用。
Int Immunopharmacol. 2015 Sep;28(1):88-96. doi: 10.1016/j.intimp.2015.05.037. Epub 2015 Jun 3.
9
Effects of Selenium-Enriched Yeast Improved Aflatoxin B1-Induced Changes in Growth Performance, Antioxidation Capacity, IL-2 and IFN-γ Contents, and Gene Expression in Mice.富硒酵母改善黄曲霉毒素 B1 诱导的小鼠生长性能、抗氧化能力、IL-2 和 IFN-γ 含量及基因表达变化的影响。
Biol Trace Elem Res. 2019 Sep;191(1):183-188. doi: 10.1007/s12011-018-1607-4. Epub 2018 Dec 15.
10
Dietary supplementation with selenium polysaccharide from selenium-enriched Phellinus linteus improves antioxidant capacity, immunity and production performance of laying hens.富硒桑黄多糖的膳食补充可提高蛋鸡的抗氧化能力、免疫力和生产性能。
J Trace Elem Med Biol. 2023 May;77:127140. doi: 10.1016/j.jtemb.2023.127140. Epub 2023 Feb 11.

引用本文的文献

1
Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice.多组学分析揭示了甲型流感病毒感染小鼠动态过程中的关键生物标志物。
Front Immunol. 2025 May 22;16:1566690. doi: 10.3389/fimmu.2025.1566690. eCollection 2025.
2
The Immune Regulation of Melanin From Brisson Against Cyclophosphamide-Induced Immunosuppression.来自布里松的黑色素对环磷酰胺诱导的免疫抑制的免疫调节作用
Food Sci Nutr. 2025 May 9;13(5):e70253. doi: 10.1002/fsn3.70253. eCollection 2025 May.
3
Effect of sakuranetin against cyclophosphamide-induced immunodeficiency mice: role of IFN-γ/TNF-α/IgG/IgM/interleukins.

本文引用的文献

1
Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis.硒缺乏性动脉炎诱导活性氧依赖中性粒细胞胞外诱捕网形成中硒蛋白 S 的作用。
Redox Biol. 2021 Aug;44:102003. doi: 10.1016/j.redox.2021.102003. Epub 2021 May 18.
2
Research progress on separation of selenoproteins/Se-enriched peptides and their physiological activities.硒蛋白/富硒肽的分离及其生理活性的研究进展
Food Funct. 2021 Mar 1;12(4):1390-1401. doi: 10.1039/d0fo02236e.
3
MiR-196-5p involvement in selenium deficiency-induced immune damage via targeting of NFκBIA in the chicken trachea.
樱花素对环磷酰胺诱导的免疫缺陷小鼠的影响：IFN-γ/TNF-α/IgG/IgM/白细胞介素的作用
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 8. doi: 10.1007/s00210-025-03988-1.
4
Protective Effects of a Sprout Hydroalcoholic Extract on Lipid Homeostasis, Hepatotoxicity, and Nephrotoxicity in Cyclophosphamide-Induced Toxicity in Rats.发芽水醇提取物对环磷酰胺诱导的大鼠毒性中脂质稳态、肝毒性和肾毒性的保护作用
Metabolites. 2024 Dec 8;14(12):690. doi: 10.3390/metabo14120690.
5
NF-κB pathway activation by Octopus peptide hydrolysate ameliorates gut dysbiosis and enhances immune response in cyclophosphamide-induced mice.章鱼肽水解物激活NF-κB通路可改善环磷酰胺诱导的小鼠肠道菌群失调并增强免疫反应。
Heliyon. 2024 Sep 24;10(19):e38370. doi: 10.1016/j.heliyon.2024.e38370. eCollection 2024 Oct 15.
6
Co-Immobilization of Alcalase/Dispase for Production of Selenium-Enriched Peptide from .共固定化碱性蛋白酶/中性蛋白酶用于从……生产富硒肽
Foods. 2024 Jun 3;13(11):1753. doi: 10.3390/foods13111753.
7
Identification and characterization of immunomodulatory peptides from pepsin-soy protein hydrolysates.胃蛋白酶水解大豆蛋白免疫调节肽的鉴定与表征
Bioresour Bioprocess. 2022 Apr 4;9(1):39. doi: 10.1186/s40643-022-00526-2.
8
Selenium-Enriched Soybean Peptides as Novel Organic Selenium Compound Supplements: Inhibition of Occupational Air Pollution Exposure-Induced Apoptosis in Lung Epithelial Cells.富硒大豆肽作为新型有机硒化合物补充剂：抑制职业性空气污染暴露诱导的肺上皮细胞凋亡。
Nutrients. 2023 Dec 25;16(1):71. doi: 10.3390/nu16010071.
9
Purification and characterization of a novel immunoregulatory peptide from L. protein.从L.蛋白中纯化和鉴定一种新型免疫调节肽
Food Sci Nutr. 2023 Sep 26;11(12):7779-7790. doi: 10.1002/fsn3.3695. eCollection 2023 Dec.
10
ZTHY2 Attenuates Cyclophosphamide-Induced Immunosuppression in Mice.ZTHY2减轻环磷酰胺诱导的小鼠免疫抑制。
Animals (Basel). 2023 Oct 31;13(21):3376. doi: 10.3390/ani13213376.
miR-196-5p 通过靶向 NFκBIA 参与硒缺乏诱导的鸡气管免疫损伤。
Metallomics. 2020 Nov 1;12(11):1679-1692. doi: 10.1039/d0mt00164c. Epub 2020 Sep 10.
4
Selenium and viral infection: are there lessons for COVID-19?硒与病毒感染：对 COVID-19 有何启示？
Br J Nutr. 2021 Mar 28;125(6):618-627. doi: 10.1017/S0007114520003128. Epub 2020 Aug 6.
5
Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors.大豆蛋白衍生肽营养剂通过调节白细胞和免疫因子，增加老年大鼠烧伤诱导的炎症应激反应中的负氮平衡。
Food Nutr Res. 2020 Jun 29;64. doi: 10.29219/fnr.v64.3677. eCollection 2020.
6
Selenium deficiency causes immune damage by activating the DUSP1/NF-κB pathway and endoplasmic reticulum stress in chicken spleen.硒缺乏通过激活 DUSP1/NF-κB 通路和鸡脾脏内质网应激导致免疫损伤。
Food Funct. 2020 Jul 1;11(7):6467-6475. doi: 10.1039/d0fo00394h. Epub 2020 Jul 3.
7
A role for selenium-dependent GPX1 in SARS-CoV-2 virulence.硒依赖的谷胱甘肽过氧化物酶1在新型冠状病毒毒力中的作用。
Am J Clin Nutr. 2020 Aug 1;112(2):447-448. doi: 10.1093/ajcn/nqaa177.
8
Association between regional selenium status and reported outcome of COVID-19 cases in China.中国区域硒状态与新冠病毒疾病病例报告结果之间的关联
Am J Clin Nutr. 2020 Jun 1;111(6):1297-1299. doi: 10.1093/ajcn/nqaa095.
9
Effects of Polysaccharide from Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice.考恩花多糖对环磷酰胺致免疫抑制和氧化应激模型小鼠的作用。
Oxid Med Cell Longev. 2020 Mar 12;2020:1603735. doi: 10.1155/2020/1603735. eCollection 2020.
10
Mesona chinensis Benth polysaccharides protect against oxidative stress and immunosuppression in cyclophosphamide-treated mice via MAPKs signal transduction pathways.Mesona chinensis Benth 多糖通过 MAPKs 信号转导通路保护环磷酰胺处理的小鼠免受氧化应激和免疫抑制。
Int J Biol Macromol. 2020 Jun 1;152:766-774. doi: 10.1016/j.ijbiomac.2020.02.318. Epub 2020 Feb 28.