Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, Brazil; Instituto de Microbiologia Paulo de Góes da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Instituto de Microbiologia Paulo de Góes da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Eur J Cell Biol. 2022 Apr;101(2):151205. doi: 10.1016/j.ejcb.2022.151205. Epub 2022 Feb 9.
Fungal extracellular vesicles (EVs) have attracted increased attention in recent years. Originated from a serendipitous discovery, the initial observation of fungal EVs resulted in a set of data repetitively rejected by several scientific journals, which raised questions about their authenticity. However, after the most fundamental experimental issues related to their observation were addressed, fungal EVs were characterized in dozens of species and became an emerging field. In this essay, we will discuss these fundamental findings and the potential of fungal EVs for the development of vaccines and antifungals.
近年来，真菌细胞外囊泡（EVs）引起了越来越多的关注。真菌 EVs 的最初观察结果源于一个偶然的发现，但最初的数据被几家科学期刊反复拒绝，这引发了对其真实性的质疑。然而，在解决了与观察相关的最基本的实验问题之后，真菌 EVs 在数十个物种中得到了表征，成为一个新兴领域。在本文中，我们将讨论这些基本发现以及真菌 EVs 在疫苗和抗真菌药物开发方面的潜力。
