Laboratory of Systems Pharmacology, Ludwig Center for Cancer Research at Harvard, Harvard Medical School, Boston, MA, USA.
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nat Methods. 2022 Mar;19(3):262-267. doi: 10.1038/s41592-022-01415-4.
The imminent release of tissue atlases combining multi-channel microscopy with single cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards that guide data deposition, curation and release. We describe a Minimum Information about highly multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and other microscopy data to highly multiplexed tissue images and traditional histology.
即将发布的组织图谱结合了多通道显微镜技术、单细胞测序以及正常和病变样本的其他组学数据，这就迫切需要数据和元数据标准来指导数据的存储、管理和发布。我们描述了一个关于高通量组织成像的最低信息标准（MITI），该标准将为基因组学和其他显微镜数据制定的最佳实践应用于高通量组织图像和传统组织学。
