Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz, 55128, Germany.
Adv Sci (Weinh). 2022 Jul;9(19):e2200059. doi: 10.1002/advs.202200059. Epub 2022 Mar 27.
Measuring certain quantities at the nanoscale is often limited to strict conditions such as low temperature or vacuum. However, the recently developed nanodiamond (ND) quantum sensing technology shows great promise for ultrasensitive diagnosis and probing subcellular parameters at ambient conditions. Atom defects (i.e., N, Si) within the ND lattice provide stable emissions and sometimes spin-dependent photoluminescence. These unique properties endow ND quantum sensors with the capacity to detect local temperature, magnetic fields, electric fields, or strain. In this review, some of the recent, most exciting developments in the preparation and application of ND sensors to solve current challenges in biology and medicine including ultrasensitive detection of virions and local sensing of pH, radical species, magnetic fields, temperature, and rotational movements, are discussed.
在纳米尺度上测量某些量通常受到严格条件的限制，例如低温或真空。然而，最近开发的纳米金刚石 (ND) 量子传感技术在环境条件下进行超灵敏诊断和探测亚细胞参数方面显示出巨大的前景。ND 晶格中的原子缺陷（例如 N、Si）提供稳定的发射，有时还具有自旋依赖的光致发光。这些独特的性质使 ND 量子传感器能够检测局部温度、磁场、电场或应变。在这篇综述中，讨论了 ND 传感器的制备和应用方面的一些最新、最令人兴奋的进展，以解决生物学和医学中的当前挑战，包括病毒的超灵敏检测以及 pH 值、自由基种类、磁场、温度和旋转运动的局部感应。
