由重复酵母基因之间的高频减数分裂重组产生的染色体易位。
Chromosomal translocations generated by high-frequency meiotic recombination between repeated yeast genes.
作者信息
Jinks-Robertson S, Petes T D
出版信息
Genetics. 1986 Nov;114(3):731-52. doi: 10.1093/genetics/114.3.731.
Abstract
We have examined meiotic and mitotic recombination between repeated genes on nonhomologous chromosomes in the yeast Saccharomyces cerevisiae. The results of these experiments can be summarized in three statements. First, gene conversion events between repeats on nonhomologous chromosomes occur frequently in meiosis. The frequency of such conversion events is only 17-fold less than the analogous frequency of conversion between genes at allelic positions on homologous chromosomes. Second, meiotic and mitotic conversion events between repeated genes on nonhomologous chromosomes are associated with reciprocal recombination to the same extent as conversion between allelic sequences. The reciprocal exchanges between the repeated genes result in chromosomal translocations. Finally, recombination between repeated genes on nonhomologous chromosomes occurs much more frequently in meiosis than in mitosis.
摘要
我们研究了酿酒酵母中非同源染色体上重复基因之间的减数分裂和有丝分裂重组。这些实验结果可归纳为三点。第一，非同源染色体上重复序列间的基因转换事件在减数分裂中频繁发生。此类转换事件的频率仅比同源染色体上等位基因位置的基因间类似转换频率低17倍。第二，非同源染色体上重复基因间的减数分裂和有丝分裂转换事件与相互重组的关联程度，与等位序列间的转换相同。重复基因间的相互交换会导致染色体易位。最后，非同源染色体上重复基因间的重组在减数分裂中比在有丝分裂中发生得更为频繁。
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