Khatami Mehrdad, Alijani Hajar Q, Mousazadeh Farideh, Hashemi Nooshin, Mahmoudi Zahra, Darijani Samaneh, Bamorovat Mehdi, Keyhani Alireza, Abdollahpour-Alitappeh Meghdad, Borhani Fariba
Noncommunicable Diseases Research Center, Bam University of Medical Sciences Bam Iran
Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences Kerman Iran.
RSC Adv. 2020 Oct 14;10(62):38063-38068. doi: 10.1039/d0ra04503a. eCollection 2020 Oct 12.
The synthesis of inorganic rod shape nanostructures is important in chromatography, dentistry, and medical applications such as bone implants, and drug and gene delivery systems. Herein, calcium carbonate (CaCO) nanowires were synthesized using a plant extract and the ensuing nanoparticles were characterized by XRD, FESEM, and HR-TEM. Then, the leishmanicidal effects of biogenic calcium carbonate nanowires were investigated against including the toxicity of varying concentrations of nanoparticles, and the percentage of viable and apoptotic cells based on flow cytometry analysis. Based on the results, the IC of these polymorphs were calculated to be 800 μg mL. An ecofriendly, inexpensive, and novel biogenic method for the production of a new advanced inorganic nanostructure, CaCO nanowires, is described without using hazardous chemicals; calcium carbonate nanowires maybe used as a smart drug carrier.
无机棒状纳米结构的合成在色谱分析、牙科以及诸如骨植入物、药物和基因递送系统等医学应用中具有重要意义。在此，使用植物提取物合成了碳酸钙（CaCO）纳米线，并通过X射线衍射（XRD）、场发射扫描电子显微镜（FESEM）和高分辨率透射电子显微镜（HR-TEM）对所得纳米颗粒进行了表征。然后，研究了生物源碳酸钙纳米线对利什曼原虫的杀伤作用，包括不同浓度纳米颗粒的毒性，以及基于流式细胞术分析的活细胞和凋亡细胞百分比。根据结果，计算出这些多晶型物的半数抑制浓度（IC）为800μg/mL。本文描述了一种环保、廉价且新颖的生物源方法，用于生产一种新型先进无机纳米结构——碳酸钙纳米线，且不使用危险化学品；碳酸钙纳米线可作为智能药物载体。
