Archana K M, Rajagopal Revathy, Krishnaswamy Veena Gayathri, Aishwarya S
Department of Chemistry, Stella Maris College (Autonomous), Affiliated to University of Madras, Chennai, India.
Department of Biotechnology, Stella Maris College (Autonomous), Affiliated to University of Madras, Chennai, India.
J Mater Res Technol. 2021 Nov-Dec;15:2102-2116. doi: 10.1016/j.jmrt.2021.09.020. Epub 2021 Sep 14.
Microorganisms cause variety of diseases that constitutes a severe threat to mankind. Due to the upsurge of many infectious diseases, there is a high requirement and demand for the development of safety products finished with antimicrobial properties. The study involves the antimicrobial activity of natural cotton coated with copper iodide capped with L. flower extract (CuI-FE) which is rich in anthocyanin, cyanidin-3-sophoroside by ultrasonication method. The coated and uncoated cotton fabric was characterised through XRD, SEM, AFM, tensile strength and UV-Visible spectroscopic techniques. XRD confirmed the formation of CuI particles, SEM showed that CuI-FE was prismatic in shape. The average size of CuI-FE particles was found to be 552.45 nm. Anti-bacterial studies showed copper iodide particles to be a potent antimicrobial agent. AFM images confirmed the rupture of bacterial cell walls in the presence of prismatic CuI-FE. cytotoxicity investigation of CuI-FE was performed against cancer and spleen cell lines to evaluate the cell viability. Cytotoxicity analysis revealed the IC value of 233.93 μg/mL in the presence of CuI-FE. Molecular docking study was also carried out to understand the interaction of CuI-FE with COVID-19 main protease. This paper has given an insight on the usage of CuI-FE coated on the cotton fabric that has proved to have strong inhibition against the nano ranged bacterial, cancerous cell line and a strong interaction with the COVID-19 protease. Such eco-friendly material will provide a safe environment even after the disposable of medical waste from the infectious diseases like influenza and current pandemic like COVID-19.
微生物引发了各种各样的疾病，对人类构成了严重威胁。由于许多传染病的激增，对抗菌性能的安全产品的开发有很高的要求和需求。该研究涉及通过超声法对涂有碘化铜并 capped with L. flower extract（富含花青素矢车菊素 -3-槐糖苷）的天然棉花（CuI-FE）的抗菌活性进行研究。通过XRD、SEM、AFM、拉伸强度和紫外可见光谱技术对涂覆和未涂覆的棉织物进行了表征。XRD证实了CuI颗粒的形成，SEM表明CuI-FE呈棱柱形。发现CuI-FE颗粒的平均尺寸为552.45纳米。抗菌研究表明碘化铜颗粒是一种有效的抗菌剂。AFM图像证实了在棱柱形CuI-FE存在下细菌细胞壁的破裂。对CuI-FE针对癌细胞系和脾细胞系进行了细胞毒性研究，以评估细胞活力。细胞毒性分析显示在CuI-FE存在下IC值为233.93μg/mL。还进行了分子对接研究以了解CuI-FE与COVID-19主要蛋白酶的相互作用。本文深入探讨了涂覆在棉织物上的CuI-FE的用途，事实证明其对纳米级细菌、癌细胞系具有强大的抑制作用，并与COVID-19蛋白酶有很强的相互作用。这种环保材料即使在处理流感等传染病和当前如COVID-19大流行的医疗废物后也能提供一个安全的环境。 （注：原文中“capped with L. flower extract”表述不太清晰准确，可能存在信息缺失，这里按字面翻译）
