Collge of Food Science and Technology, Hebei Agricultural University, Baoding, China.
Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Technology & Food Sciences Unit, Melle, Belgium.
Gut Microbes. 2022 Jan-Dec;14(1):2126274. doi: 10.1080/19490976.2022.2126274.
The use of probiotics has been one of the effective strategies to restructure perturbed human gut microbiota following a disease or metabolic disorder. One of the biggest challenges associated with the use of probiotic-based gut modulation strategies is to keep the probiotic cells viable and stable during the gastrointestinal transit. Biofilm-based probiotics delivery approaches have emerged as fascinating modes of probiotic delivery in which probiotics show significantly greater tolerance and biotherapeutic potential, and interestingly probiotic biofilms can be developed on food-grade surfaces too, which is ideal for the growth and proliferation of bacterial cells for incorporation into food matrices. In addition, biofilms can be further encapsulated with food-grade materials or with bacterial self-produced biofilms. This review presents a newly emerging and unprecedently discussed techniques for the safe delivery of probiotics based on biofilms and further discusses newly emerging prebiotic materials which target specific gut microbiota groups for growth and proliferation.
益生菌的使用是在疾病或代谢紊乱后重建受干扰的人类肠道微生物群的有效策略之一。使用基于益生菌的肠道调节策略的最大挑战之一是在胃肠道转运过程中保持益生菌细胞的存活和稳定。基于生物膜的益生菌传递方法已成为益生菌传递的一种引人注目的方式，其中益生菌表现出更高的耐受性和生物治疗潜力，有趣的是，益生菌生物膜也可以在食品级表面上形成，这非常有利于细菌细胞的生长和增殖，以便纳入食物基质。此外，生物膜可以进一步用食品级材料或细菌自身产生的生物膜进行封装。本综述介绍了一种基于生物膜的新型益生菌安全传递技术，并进一步讨论了新出现的针对特定肠道微生物群生长和增殖的后生元材料。
