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副干酪乳杆菌BBM171通过调节Th1/Th2平衡改善卵清蛋白诱导的小鼠过敏性气道炎症。

Lactobacillus paragasseri BBM171 Ameliorates Allergic Airway Inflammation Induced by Ovalbumin in Mice via Modulating the Th1/Th2 Balance.

作者信息

Cheng Shih-Hsuan, Yang Tzu-Ying, Hsu Chih-Chieh, Wei Yu-Hsuan, Wu Chien-Chen, Tsai Ying-Chieh

机构信息

Bened Biomedical Co., Ltd., Taipei 10448, Taiwan.

Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.

出版信息

Microorganisms. 2022 Oct 15;10(10):2041. doi: 10.3390/microorganisms10102041.

DOI:10.3390/microorganisms10102041
PMID:36296316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9611844/
Abstract

Supplementation with specific probiotics has been shown to improve allergic airway symptoms. This study aimed to investigate immunomodulatory effects of a potential probiotic strain isolated from breast milk, Lactobacillus paragasseri BBM171 (BBM171), in an ovalbumin (OVA)-induced allergic mouse model. OVA-sensitized and OVA-challenged BALB/c mice were orally administered live or heat-inactivated BBM171 for 48 consecutive days. After the last allergen challenge, serum immunoglobulin (Ig) levels, inflammatory cell levels in the lungs, and cytokine levels in bronchoalveolar lavage fluid (BALF) were assessed. The results showed that oral administration of live or heat-inactivated BBM171 decreased serum levels of total IgE, OVA-specific IgE, and OVA-specific IgG1, while increasing OVA-specific IgG2a and reducing the extent of airway inflammation in OVA-induced allergic mice. In addition, both live and heat-inactivated BBM171 modulated the cytokine profile in BALF to a type 1 T helper (Th1) response. Furthermore, ex vivo experiments using OVA-induced allergic mouse splenocytes showed that both live and heat-inactivated BBM171 could regulate the Th1/Th2 balance, decrease the proinflammatory cytokine interleukin (IL)-17 level, and increase the anti-inflammatory cytokine IL-10 level. Taken together, these results suggest that oral administration of live or heat-inactivated BBM171 improved allergen-induced airway inflammation symptoms by modulating the host immune response toward Th1 dominance.

摘要

已证明补充特定益生菌可改善过敏性气道症状。本研究旨在调查从母乳中分离出的潜在益生菌菌株副干酪乳杆菌BBM171（BBM171）在卵清蛋白（OVA）诱导的过敏性小鼠模型中的免疫调节作用。将OVA致敏和OVA激发的BALB/c小鼠连续48天口服给予活的或热灭活的BBM171。在最后一次过敏原激发后，评估血清免疫球蛋白（Ig）水平、肺中的炎症细胞水平以及支气管肺泡灌洗液（BALF）中的细胞因子水平。结果表明，口服活的或热灭活的BBM171可降低血清总IgE、OVA特异性IgE和OVA特异性IgG1水平，同时增加OVA特异性IgG2a并减轻OVA诱导的过敏性小鼠的气道炎症程度。此外，活的和热灭活的BBM171均将BALF中的细胞因子谱调节为1型辅助性T细胞（Th1）反应。此外，使用OVA诱导的过敏性小鼠脾细胞进行的体外实验表明，活的和热灭活的BBM171均可调节Th1/Th2平衡，降低促炎细胞因子白细胞介素（IL）-17水平，并增加抗炎细胞因子IL-10水平。综上所述，这些结果表明，口服活的或热灭活的BBM171可通过调节宿主免疫反应使其向Th1优势方向发展，从而改善过敏原诱导的气道炎症症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/1d14c48b8527/microorganisms-10-02041-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/cd7ecf006838/microorganisms-10-02041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/5a5d6f45b5b5/microorganisms-10-02041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/5f681e3e920f/microorganisms-10-02041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/aeb9fd7c9c28/microorganisms-10-02041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/231ae9098897/microorganisms-10-02041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/e5a77a57986e/microorganisms-10-02041-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/1d14c48b8527/microorganisms-10-02041-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/cd7ecf006838/microorganisms-10-02041-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/5a5d6f45b5b5/microorganisms-10-02041-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/5f681e3e920f/microorganisms-10-02041-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/aeb9fd7c9c28/microorganisms-10-02041-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/231ae9098897/microorganisms-10-02041-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/e5a77a57986e/microorganisms-10-02041-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3a/9611844/1d14c48b8527/microorganisms-10-02041-g007.jpg

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