School of Mechanical Engineering, Hanoi University of Science and Technology, Hanoi 100000, Vietnam.
College of Engineering and Computer Science, VinUniversity, Hanoi 100000, Vietnam.
Sensors (Basel). 2023 Mar 6;23(5):2841. doi: 10.3390/s23052841.
The primary goal of glucose sensing at the point of care is to identify glucose concentrations within the diabetes range. However, lower glucose levels also pose a severe health risk. In this paper, we propose quick, simple, and reliable glucose sensors based on the absorption and photoluminescence spectra of chitosan-capped ZnS-doped Mn nanomaterials in the range of 0.125 to 0.636 mM glucose corresponding to 2.3 mg/dL to 11.4 mg/dL. The detection limit was 0.125 mM (or 2.3 mg/dL), much lower than the hypoglycemia level of 70 mg/dL (or 3.9 mM). Chitosan-capped ZnS-doped Mn nanomaterials retain their optical properties while improving sensor stability. This study reports for the first time how the sensors' efficacy was affected by chitosan content from 0.75 to 1.5 wt.%. The results showed that 1 %wt chitosan-capped ZnS-doped Mn is the most-sensitive, -selective, and -stable material. We also put the biosensor through its paces with glucose in phosphate-buffered saline. In the same range of 0.125 to 0.636 mM, the sensors-based chitosan-coated ZnS-doped Mn had a better sensitivity than the working water environment.
在即时检测点，葡萄糖检测的主要目标是识别糖尿病范围内的葡萄糖浓度。然而，较低的葡萄糖水平也会对健康造成严重威胁。在本文中，我们提出了基于壳聚糖包覆的 ZnS 掺杂 Mn 纳米材料在 0.125 至 0.636mM 葡萄糖（对应于 2.3 至 11.4mg/dL）范围内的吸收和光致发光光谱的快速、简单和可靠的葡萄糖传感器。检测限为 0.125mM（或 2.3mg/dL），远低于 70mg/dL（或 3.9mM）的低血糖水平。壳聚糖包覆的 ZnS 掺杂 Mn 纳米材料在提高传感器稳定性的同时保持了其光学性能。本研究首次报道了壳聚糖含量从 0.75 至 1.5wt.%如何影响传感器的效能。结果表明，1wt.%壳聚糖包覆的 ZnS 掺杂 Mn 是最敏感、最具选择性和最稳定的材料。我们还在磷酸盐缓冲盐水（PBS）中的葡萄糖中对生物传感器进行了测试。在相同的 0.125 至 0.636mM 范围内，基于壳聚糖涂层的 ZnS 掺杂 Mn 的传感器比工作水环境具有更好的灵敏度。
