Department of Polymer Science, The University of Akron, Akron, Ohio 44325, United States.
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44106, United States.
Biomacromolecules. 2020 Oct 12;21(10):4030-4042. doi: 10.1021/acs.biomac.0c00801. Epub 2020 Sep 23.
Thread size and polymer composition are critical properties to consider for achieving a positive healing outcome with a wound dressing. Three-dimensional (3D) printed scaffolds and electrospun mats both offer distinct advantages as replaceable wound dressings. This research aims to determine if the thread size and polymer compositions of the scaffolds affect skin wound healing outcomes, an aspect that has not been adequately explored. Using a modular polymer platform, four polyester direct-write 3D printed scaffolds and electrospun mats were fabricated into wound dressings. The dressings were applied to splinted, full thickness skin wounds in an excisional wound rat model and evaluated against control wounds to which no dressing was applied. Wound closure rates and reduction of the wound bed width were not affected by the thread size or polymer composition. However, epidermal thickness was larger in wounds treated with electrospun dressings and was slightly affected by the polymer composition. Two of the four tested polymer compositions lead to delayed reorganization of granulation tissues. Moreover, enhanced angiogenesis was seen in wounds treated with 3D printed dressings compared to those treated with electrospun dressings. The results from this study can be used to inform the choice of dressing architecture and polymer compositions to achieve positive wound healing outcomes.
缝线大小和聚合物组成是影响伤口敷料治疗效果的关键因素。三维（3D）打印支架和静电纺丝垫都作为可替换的伤口敷料具有明显的优势。本研究旨在确定支架的缝线大小和聚合物组成是否会影响皮肤伤口愈合的结果，这方面尚未得到充分的研究。本研究使用模块化聚合物平台，将四种聚酯直接写入 3D 打印支架和静电纺丝垫制成伤口敷料。将这些敷料应用于夹板状全厚度皮肤伤口的切除伤口大鼠模型，并与未应用敷料的对照伤口进行比较。缝线大小或聚合物组成对伤口闭合率和伤口床宽度的减少没有影响。然而，用静电纺丝敷料处理的伤口表皮厚度更大，并且受聚合物组成的轻微影响。测试的四种聚合物组成中有两种导致肉芽组织的重新组织延迟。此外，与用静电纺丝敷料处理的伤口相比，用 3D 打印敷料处理的伤口可见血管生成增强。本研究的结果可用于指导选择敷料结构和聚合物组成，以实现积极的伤口愈合结果。
