在临床标本中，通过免疫荧光法比较多克隆抗血清与单克隆抗体用于甲型流感病毒感染快速诊断的效果。
Comparison of polyclonal antiserum versus monoclonal antibodies for the rapid diagnosis of influenza A virus infections by immunofluorescence in clinical specimens.
作者信息
Shalit I, McKee P A, Beauchamp H, Waner J L
出版信息
J Clin Microbiol. 1985 Nov;22(5):877-9. doi: 10.1128/jcm.22.5.877-879.1985.
Abstract
A pool of monoclonal antibodies was compared with polyclonal antiserum for the rapid detection of influenza A virus in 28 clinical specimens by immunofluorescence. Monoclonal antibodies showed higher sensitivity (69 versus 46%) and accuracy (86 versus 75%) and easier slide interpretation than did polyclonal antiserum. The procedure proved useful for rapid detection of a community outbreak of influenza A virus infection.
摘要
通过免疫荧光法，比较了一组单克隆抗体与多克隆抗血清用于快速检测28份临床标本中甲型流感病毒的效果。与多克隆抗血清相比，单克隆抗体显示出更高的灵敏度（分别为69%和46%）和准确性（分别为86%和75%），且玻片判读更容易。该方法被证明对快速检测甲型流感病毒感染的社区暴发有用。
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