Zhang Xingxing, Zhang Xinru, Li Ruihua, Lin Meiyan, Ou Tongyin, Zhou Hu, Chen Zhiming, Zhen Li
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
School of Nursing, Southern Medical University, Guangzhou, China.
Front Nutr. 2024 Jul 22;11:1431962. doi: 10.3389/fnut.2024.1431962. eCollection 2024.
Globally, diet low in milk is the third greatest risk factor for colorectal cancer (CRC). However, there has been a lack of detailed worldwide analysis of the burden and trends of CRC attributable to diet low in milk.
We aim to assess the spatiotemporal trends of CRC-related mortality and disability-adjusted life-years (DALYs) attributable to diet low in milk at the global, regional, and national levels from 1990 to 2019.
Data of mortality, DALYs, age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) of CRC attributable to diet low in milk were extracted from the Global Burden of Disease (GBD) 2019 study. The burden of CRC attributable to diet low in milk was estimated using the ASMR and ASDR, while accounting for sex, age, country, and socio-demographic index (SDI). From 1990 to 2019, the estimated annual percentage change (EAPC) was calculated to clarify the temporal trends in the ASMR and ASDR attributable to diet low in milk.
In 2019, there were 166,456 (95% UI = 107,221-226,027) deaths and 3,799,297 (95% UI = 2,457,768-5,124,453) DALYs attributable to diet low in milk, accounting for 15.3 and 15.6% of CRC-related deaths and DALYs in 2019. CRC-related deaths and DALYs attributed to diet low in milk increased by 130.5 and 115.4%, from 1990 to 2019. The burden of CRC attributable to diet low in milk varied notably among regions and nations. High-middle SDI regions had the highest ASDR and ASMR of CRC linked to diet low in milk, while there was a slight downward trend high SDI regions. Among geographical regions, East Asia had the highest number of CRC-related deaths and DALYs attributable to diet low in milk. Notably, the burden of CRC was highest in males and the elderly. With coefficients of -0.36 and -0.36, the EAPC in ASMR and ASDR was significantly inversely correlated with the Human Development Index in 2019.
Globally, the number of CRC deaths attributable to diet low in milk has continued to increase over the last 30 years. Therefore, government and authorities should conduct education campaigns to encourage individuals to increase daily milk intake.
在全球范围内，牛奶摄入量低的饮食是结直肠癌（CRC）的第三大风险因素。然而，目前缺乏对牛奶摄入量低的饮食导致的结直肠癌负担和趋势进行详细的全球分析。
我们旨在评估1990年至2019年全球、区域和国家层面上，因牛奶摄入量低的饮食导致的结直肠癌相关死亡率和伤残调整生命年（DALYs）的时空趋势。
从《2019年全球疾病负担（GBD）》研究中提取因牛奶摄入量低的饮食导致的结直肠癌死亡率、DALYs、年龄标准化死亡率（ASMR）和年龄标准化DALY率（ASDR）的数据。使用ASMR和ASDR估算因牛奶摄入量低的饮食导致的结直肠癌负担，同时考虑性别、年龄、国家和社会人口指数（SDI）。计算1990年至2019年的估计年度百分比变化（EAPC），以阐明因牛奶摄入量低的饮食导致的ASMR和ASDR的时间趋势。
2019年，因牛奶摄入量低的饮食导致166,456例（95%UI = 107,221 - 226,027）死亡和3,799,297例（95%UI = 2,457,768 - 5,124,453）DALYs，分别占2019年结直肠癌相关死亡和DALYs的15.3%和15.6%。从1990年到2019年，因牛奶摄入量低的饮食导致的结直肠癌相关死亡和DALYs分别增加了130.5%和115.4%。因牛奶摄入量低的饮食导致的结直肠癌负担在不同地区和国家之间差异显著。高中等SDI地区因牛奶摄入量低的饮食导致的结直肠癌ASDR和ASMR最高，而高SDI地区呈轻微下降趋势。在地理区域中，东亚因牛奶摄入量低的饮食导致的结直肠癌相关死亡和DALYs数量最多。值得注意的是，结直肠癌负担在男性和老年人中最高。2019年，ASMR和ASDR的EAPC系数分别为-0.36，与人类发展指数显著负相关。
在全球范围内，过去30年中因牛奶摄入量低的饮食导致的结直肠癌死亡人数持续增加。因此，政府和有关部门应开展教育活动，鼓励个人增加每日牛奶摄入量。
