Yoon Jong Hyuk, Lee Hagyeong, Kwon Dayoung, Lee Dongha, Lee Seulah, Cho Eunji, Kim Jaehoon, Kim Dayea
Neurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.
Cognitive Science Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.
Brain Commun. 2024 Aug 8;6(4):fcae265. doi: 10.1093/braincomms/fcae265. eCollection 2024.
Treatments that can completely resolve brain diseases have yet to be discovered. Omics is a novel technology that allows researchers to understand the molecular pathways underlying brain diseases. Multiple omics, including genomics, transcriptomics and proteomics, and brain imaging technologies, such as MRI, PET and EEG, have contributed to brain disease-related therapeutic target detection. However, new treatment discovery remains challenging. We focused on establishing brain multi-molecular maps using an integrative approach of omics and imaging to provide insights into brain disease diagnosis and treatment. This approach requires precise data collection using omics and imaging technologies, data processing and normalization. Incorporating a brain molecular map with the advanced technologies through artificial intelligence will help establish a system for brain disease diagnosis and treatment through regulation at the molecular level.
能够完全治愈脑部疾病的治疗方法尚未被发现。组学是一项新技术，它使研究人员能够了解脑部疾病背后的分子途径。多种组学，包括基因组学、转录组学和蛋白质组学，以及脑部成像技术，如核磁共振成像（MRI）、正电子发射断层扫描（PET）和脑电图（EEG），都有助于检测与脑部疾病相关的治疗靶点。然而，发现新的治疗方法仍然具有挑战性。我们专注于使用组学和成像的综合方法来建立脑部多分子图谱，以深入了解脑部疾病的诊断和治疗。这种方法需要使用组学和成像技术进行精确的数据收集、数据处理和标准化。通过人工智能将脑部分子图谱与先进技术相结合，将有助于建立一个通过分子水平调控进行脑部疾病诊断和治疗的系统。
