短暂接触氯霉素后白细胞对大肠杆菌活性的增强。
Enhancement of leukocyte activity against Escherichia coli after brief exposure to chloramphenicol.
作者信息
Pruul H, McDonald P J
出版信息
Antimicrob Agents Chemother. 1979 Dec;16(6):695-700. doi: 10.1128/AAC.16.6.695.
Abstract
The effect of brief exposure of Escherichia coli to chloramphenicol on the antibacterial activity of normal human leukocytes was studied by following changes in viability of the bacteria in the presence of leukocytes and serum. Growth was suppressed, and the extent of suppression was directly related to the period of exposure and the concentration of chloramphenicol. When exposed to clinically achievable levels of the drug for 10 min, E. coli failed to resume normal growth for 1 to 4 h in the presence of leukocytes and serum after removal of the drug. The post-antibiotic leukocyte enhancement effect required the presence of antibody and complement. This effect demonstrates the importance of early events in the encounter between antibiotic and microorganism in determining the subsequent activity of host defense components.
摘要
通过追踪在白细胞和血清存在的情况下细菌活力的变化，研究了大肠杆菌短暂暴露于氯霉素对正常人白细胞抗菌活性的影响。细菌生长受到抑制，抑制程度与暴露时间和氯霉素浓度直接相关。当暴露于临床可达到的药物水平10分钟时，去除药物后，大肠杆菌在白细胞和血清存在的情况下1至4小时内无法恢复正常生长。抗生素后白细胞增强效应需要抗体和补体的存在。这种效应表明了抗生素与微生物相遇早期事件在决定宿主防御成分后续活性方面的重要性。
相似文献
1
Enhancement of leukocyte activity against Escherichia coli after brief exposure to chloramphenicol.短暂接触氯霉素后白细胞对大肠杆菌活性的增强。
Antimicrob Agents Chemother. 1979 Dec;16(6):695-700. doi: 10.1128/AAC.16.6.695.
2
Enhanced susceptibility of Escherichia coli to intracellular killing by human polymorphonuclear leukocytes after in vitro incubation with chloramphenicol.体外与氯霉素孵育后，大肠杆菌对人多形核白细胞细胞内杀伤作用的敏感性增强。
Antimicrob Agents Chemother. 1981 Jun;19(6):945-51. doi: 10.1128/AAC.19.6.945.
3
Postantibiotic leukocyte enhancement: increased susceptibility of bacteria pretreated with antibiotics to activity of leukocytes.抗生素后白细胞增强：用抗生素预处理的细菌对白细胞活性的敏感性增加。
Rev Infect Dis. 1981 Jan-Feb;3(1):38-44. doi: 10.1093/clinids/3.1.38.
4
Effect of catecholamines on the bactericidal activity of polymorphonuclear leukocytes.儿茶酚胺对多形核白细胞杀菌活性的影响。
Infect Immun. 1972 Sep;6(3):211-7. doi: 10.1128/iai.6.3.211-217.1972.
5
6
Bactericidal activity of the combinations of gentamicin with clindamycin or chloramphenicol against species of Escherichia coli and Bacteroides fragilis.庆大霉素与克林霉素或氯霉素联合使用对大肠杆菌和脆弱拟杆菌的杀菌活性。
Antimicrob Agents Chemother. 1977 Aug;12(2):135-8. doi: 10.1128/AAC.12.2.135.
7
Induction of complement sensitivity in Escherichia coli by citric acid and low pH.柠檬酸和低pH值诱导大肠杆菌的补体敏感性
J Appl Microbiol. 2001 May;90(5):771-8. doi: 10.1046/j.1365-2672.2001.01305.x.
8
Cefdinir-induced modification of the susceptibility of bacteria to the antibacterial activity of human serum and polymorphonuclear neutrophils.头孢地尼诱导细菌对人血清和多形核中性粒细胞抗菌活性敏感性的改变。
Eur J Clin Microbiol Infect Dis. 1993 Mar;12(3):170-6. doi: 10.1007/BF01967107.
9
Enhanced susceptibility of Escherichia coli pretreated with RP7293 to leukocyte activity: comparison with other antimicrobial agents.用RP7293预处理的大肠杆菌对白细胞活性的敏感性增强：与其他抗菌剂的比较。
Chemotherapy. 1994 Mar-Apr;40(2):99-103. doi: 10.1159/000239179.
10
Effect of growth phase on the bactericidal action of chloramphenicol against Haemophilus influenzae type b and Escherichia coli K-1.生长阶段对氯霉素针对b型流感嗜血杆菌和大肠杆菌K-1杀菌作用的影响。
Antimicrob Agents Chemother. 1983 Apr;23(4):551-4. doi: 10.1128/AAC.23.4.551.
引用本文的文献
1
Antioxidant Activity and Chemical Composition of Geranium Oil and Its Synergistic Potential against Pneumococci with Various Antibiotic Combinations.天竺葵油的抗氧化活性、化学成分及其与多种抗生素组合对肺炎球菌的协同潜力
Plants (Basel). 2023 Aug 28;12(17):3080. doi: 10.3390/plants12173080.
2
Impact Assessment of Lead-Tolerant Rhizobacteria to Improve Soil Health Using Indian Mustard () as an Indicator Plant.以印度芥菜（）作为指示植物，评估耐铅根际细菌对改善土壤健康的影响。 （注：括号里的内容原文缺失，这里按格式原样保留）
Plants (Basel). 2023 Aug 21;12(16):3005. doi: 10.3390/plants12163005.
3
Cefdinir-induced modification of the susceptibility of bacteria to the antibacterial activity of human serum and polymorphonuclear neutrophils.头孢地尼诱导细菌对人血清和多形核中性粒细胞抗菌活性敏感性的改变。
Eur J Clin Microbiol Infect Dis. 1993 Mar;12(3):170-6. doi: 10.1007/BF01967107.
4
Killing of oxacillin-exposed staphylococci in human polymorphonuclear leukocytes.人多形核白细胞中对苯唑西林敏感葡萄球菌的杀灭作用
Antimicrob Agents Chemother. 1980 Nov;18(5):807-13. doi: 10.1128/AAC.18.5.807.
5
Phagocytosis of Borrelia recurrentis by blood polymorphonuclear leukocytes is enhanced by antibiotic treatment.抗生素治疗可增强血液中多形核白细胞对回归热疏螺旋体的吞噬作用。
Infect Immun. 1980 Jun;28(3):1009-13. doi: 10.1128/iai.28.3.1009-1013.1980.
6
Influence of subinhibitory concentrations of penicillin, cephalothin, and clindamycin on Staphylococcus aureus growth in human phagocytic cells.亚抑菌浓度的青霉素、头孢噻吩和克林霉素对人吞噬细胞中金黄色葡萄球菌生长的影响。
Antimicrob Agents Chemother. 1982 Nov;22(5):781-4. doi: 10.1128/AAC.22.5.781.
7
Enhanced susceptibility of Escherichia coli to intracellular killing by human polymorphonuclear leukocytes after in vitro incubation with chloramphenicol.体外与氯霉素孵育后，大肠杆菌对人多形核白细胞细胞内杀伤作用的敏感性增强。
Antimicrob Agents Chemother. 1981 Jun;19(6):945-51. doi: 10.1128/AAC.19.6.945.
8
Effect of azlocillin and piperacillin in subinhibitory and inhibitory concentrations on Staphylococcus aureus and Pseudomonas aeruginosa in broth, in serum and in the presence of human polymorphonuclear leukocytes.阿洛西林和哌拉西林在亚抑菌浓度和抑菌浓度下对肉汤、血清中以及存在人多形核白细胞时的金黄色葡萄球菌和铜绿假单胞菌的作用。
Eur J Clin Microbiol. 1983 Oct;2(5):439-44. doi: 10.1007/BF02013901.
9
In vitro killing of erythromycin-exposed group A streptococci by polymorphonuclear leukocytes.
Eur J Clin Microbiol. 1986 Aug;5(4):405-10. doi: 10.1007/BF02075695.
本文引用的文献
1
Sensitization of complement-resistant smooth gram-negative bacterial strains.补体抗性光滑革兰氏阴性细菌菌株的致敏作用。
Infect Immun. 1971 Mar;3(3):365-72. doi: 10.1128/iai.3.3.365-372.1971.
2
Effect of polymyxin on the lysis of Neisseria catarrhalis by lysozyme.多粘菌素对溶菌酶裂解卡他莫拉菌的影响。
J Bacteriol. 1957 Dec;74(6):788-93. doi: 10.1128/jb.74.6.788-793.1957.
3
"Continuous" vs. "discontinuous" therapy with penicillin; the effect of the interval between injections on therapeutic efficacy.青霉素的“连续”与“间断”疗法；注射间隔时间对治疗效果的影响。
N Engl J Med. 1953 Mar 19;248(12):481-8. doi: 10.1056/NEJM195303192481201.
4
The sensitivity to complement of strains of Escherichia coli related to their K antigens.大肠杆菌菌株对补体的敏感性与其K抗原的关系。
Immunology. 1970 Mar;18(3):331-46.
5
Antibiotic, detergent, and complement sensitivity of Salmonella typhi after ethylenediaminetetraacetic acid treatment.乙二胺四乙酸处理后伤寒沙门氏菌对抗生素、去污剂和补体的敏感性
J Bacteriol. 1968 Jun;95(6):2010-3. doi: 10.1128/jb.95.6.2010-2013.1968.
6
The serum bactericidal reaction. IV. Phenotypic conversion of Escherichia coli from serum-resistance to serum-sensitivity by diphenylamine.
J Infect Dis. 1969 Oct;120(4):437-44. doi: 10.1093/infdis/120.4.437.
7
Membrane protein synthesis in Escherichia coli: sensitivity to chloramphenicol.
Arch Biochem Biophys. 1973 Nov;159(1):336-41. doi: 10.1016/0003-9861(73)90459-1.
8
Enhanced susceptibility of penicillin-resistant staphylococci to phagocytosis after in vitro incubation with low doses of nafcillin.耐青霉素葡萄球菌在体外与低剂量萘夫西林孵育后对吞噬作用的敏感性增强。
Proc Soc Exp Biol Med. 1974 Jul;146(3):707-11. doi: 10.3181/00379727-146-38177.
9
Effect of sublethal concentrations of penicillins on the lysis of bacteria by lysozyme and trypsin.亚致死浓度青霉素对溶菌酶和胰蛋白酶裂解细菌的影响。
Proc Soc Exp Biol Med. 1965 Nov;120(2):504-11. doi: 10.3181/00379727-120-30573.
10
Interaction of complement and polymyxin with gram-negative bacteria.补体与多粘菌素与革兰氏阴性菌的相互作用。
Infect Immun. 1972 Nov;6(5):709-17. doi: 10.1128/iai.6.5.709-717.1972.
Zotero 插件