未接触正己烷人员尿液中2,5 -己二酮的检测
Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane.
作者信息
Fedtke N, Bolt H M
出版信息
Int Arch Occup Environ Health. 1986;57(2):143-8. doi: 10.1007/BF00381382.
PMID:3949398
Abstract
The neurotoxic n-hexane metabolite 2,5-hexanedione was detected by gas chromatography--mass spectrometry in urine samples from human subjects not exposed to n-hexane or related hydrocarbons. Quantitative determinations by multiple ion detection revealed an amount of 2,5-hexanedione ranging from 0.12 to 0.78 mg/l (0.45 +/- 0.20 mg/l; means +/- SD). The amounts of 2,5-hexanedione actually measured in urinary extracts depended on the pH employed for acid hydrolysis of the samples.
摘要
通过气相色谱-质谱法在未接触正己烷或相关碳氢化合物的人体受试者的尿液样本中检测到了具有神经毒性的正己烷代谢物2,5-己二酮。通过多离子检测进行的定量测定显示，2,5-己二酮的含量在0.12至0.78毫克/升之间（0.45±0.20毫克/升；平均值±标准差）。尿液提取物中实际测得的2,5-己二酮含量取决于用于样本酸水解的pH值。
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