Perbellini L, Pezzoli G, Brugnone F, Canesi M
Institute of Occupational Medicine, Policlinico Borgo Roma, Verona, Italy.
Int Arch Occup Environ Health. 1993;65(1):49-52. doi: 10.1007/BF00586058.
This article reports results regarding two different physiological aspects of 2,5-hexanedione (2,5-HD). The first is the relationship between "free" 2,5-HD (the fraction of "real" 2,5-HD) and "total" 2,5-HD (2,5-HD obtained from acid hydrolysis) in urine and blood of workers exposed to n-hexane. The second part of the study is an attempt to clarify "physiological" excretion of 2,5-HD in subjects not occupationally exposed to n-hexane. The concentration of free 2,5-HD in urine of workers exposed to n-hexane is about 8% of total urinary 2,5-HD. In blood, free 2,5-HD is about 50% of the total. The serum concentration range of total and free 2,5-HD in workers from whom blood was taken was 33-418 micrograms/l and 14-283 micrograms/l respectively. In subjects not exposed to n-hexane, urinary concentration of 2,5-HD ranged between 0.17 and 0.98 mg/l, the urinary excretion rate between 0.23 and 0.57 microgram/min, and renal clearance between 14 and 66 ml/min. The blood concentration of 2,5-HD in nonexposed subjects was 6-30 micrograms/l. Fluctuations typical of a circadian rhythm were not observed for 2,5-HD in blood or urine. We think that 2,5-HD is mainly a product of intermediate metabolism in the human body. Only a minimal part could derive from n-hexane as a ubiquitous micropollutant.
本文报道了关于2,5 - 己二酮（2,5 - HD）两个不同生理方面的研究结果。第一个方面是接触正己烷的工人尿液和血液中“游离”2,5 - HD（“真正的”2,5 - HD部分）与“总”2,5 - HD（酸水解得到的2,5 - HD）之间的关系。研究的第二部分是试图阐明未职业接触正己烷的受试者中2,5 - HD的“生理”排泄情况。接触正己烷的工人尿液中游离2,5 - HD的浓度约为尿液中总2,5 - HD的8%。在血液中，游离2,5 - HD约占总量的50%。采集血液的工人中，总2,5 - HD和游离2,5 - HD的血清浓度范围分别为33 - 418微克/升和14 - 283微克/升。在未接触正己烷的受试者中，2,5 - HD的尿液浓度范围为0.17至0.98毫克/升，尿排泄率为0.23至0.57微克/分钟，肾清除率为14至66毫升/分钟。未接触者血液中2,5 - HD的浓度为6 - 30微克/升。在血液或尿液中未观察到2,5 - HD典型的昼夜节律波动。我们认为2,5 - HD主要是人体中间代谢的产物。只有极小部分可能来自作为普遍存在的微污染物的正己烷。
