石棉催化的脂质过氧化及其被去铁胺抑制的情况。
Asbestos-catalysed lipid peroxidation and its inhibition by desferroxamine.
作者信息
Weitzman S A, Weitberg A B
出版信息
Biochem J. 1985 Jan 1;225(1):259-62. doi: 10.1042/bj2250259.
Abstract
In an effort to understand the properties of asbestos fibres that might contribute to their being toxic, we incubated three different varieties of asbestos with phospholipid emulsions and looked for evidence of lipid peroxidation. Although all three types of asbestos were able to catalyse lipid peroxidation in the native state, this catalytic activity was inhibited by pre-washing of the asbestos with the iron chelator desferroxamine. This suggests that: lipid peroxidation may be one of the mechanisms by which asbestos produces tissue injury, and treatment with iron chelators might diminish the potential to produce this injury.
摘要
为了了解石棉纤维可能具有毒性的特性，我们将三种不同种类的石棉与磷脂乳液一起孵育，并寻找脂质过氧化的证据。尽管所有三种类型的石棉在天然状态下都能够催化脂质过氧化，但用铁螯合剂去铁胺对石棉进行预洗涤会抑制这种催化活性。这表明：脂质过氧化可能是石棉造成组织损伤的机制之一，用铁螯合剂进行治疗可能会降低产生这种损伤的可能性。
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