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使用一种新提出的深度学习模型从全切片组织病理学图像进行增强的多类别乳腺癌分类。

Enhanced Multi-Class Breast Cancer Classification from Whole-Slide Histopathology Images Using a Proposed Deep Learning Model.

作者信息

Rafiq Adnan, Jaffar Arfan, Latif Ghazanfar, Masood Sohail, Abdelhamid Sherif E

机构信息

Department of Computer Science & IT, Superior University, Lahore 54000, Pakistan.

Department of Computing Science, Thompson Rivers University, Kamloops, BC V2C 0C8, Canada.

出版信息

Diagnostics (Basel). 2025 Feb 27;15(5):582. doi: 10.3390/diagnostics15050582.

DOI:10.3390/diagnostics15050582
PMID:40075829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11899611/
Abstract

Breast cancer is among the most frequently diagnosed cancers and leading cause of mortality worldwide. The accurate classification of breast cancer from the histology photographs is very important for the diagnosis and effective treatment planning. : In this article, we propose a DenseNet121-based deep learning model for breast cancer detection and multi-class classification. The experiments were performed using whole-slide histopathology images collected from the BreakHis dataset. : The proposed method attained state-of-the-art performance with a 98.50% accuracy and an AUC of 0.98 for the binary classification. In multi-class classification, it obtained competitive results with 92.50% accuracy and an AUC of 0.94. : The proposed model outperforms state-of-the-art methods in distinguishing between benign and malignant tumors as well as in classifying specific malignancy subtypes. This study highlights the potential of deep learning in breast cancer diagnosis and establishes the foundation for developing advanced diagnostic tools.

摘要

乳腺癌是全球最常被诊断出的癌症之一,也是主要的死亡原因。从组织学照片中准确分类乳腺癌对于诊断和有效的治疗规划非常重要。在本文中,我们提出了一种基于DenseNet121的深度学习模型用于乳腺癌检测和多类别分类。实验使用了从BreakHis数据集中收集的全切片组织病理学图像。所提出的方法在二分类中达到了98.50%的准确率和0.98的AUC,取得了当前最优的性能。在多类别分类中,它获得了具有竞争力的结果,准确率为92.50%,AUC为0.94。所提出的模型在区分良性和恶性肿瘤以及对特定恶性亚型进行分类方面优于当前最优方法。这项研究突出了深度学习在乳腺癌诊断中的潜力,并为开发先进的诊断工具奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/e0c36849f729/diagnostics-15-00582-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/250a6d90ea62/diagnostics-15-00582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/11d3651f45d6/diagnostics-15-00582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/4a6735228ece/diagnostics-15-00582-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/533f5df850b7/diagnostics-15-00582-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/b6f846f287b2/diagnostics-15-00582-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/af1741f5931f/diagnostics-15-00582-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/efb48235ed4a/diagnostics-15-00582-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/130fb1f5fdcd/diagnostics-15-00582-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/e0c36849f729/diagnostics-15-00582-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/250a6d90ea62/diagnostics-15-00582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/11d3651f45d6/diagnostics-15-00582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/4a6735228ece/diagnostics-15-00582-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/533f5df850b7/diagnostics-15-00582-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/b6f846f287b2/diagnostics-15-00582-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/af1741f5931f/diagnostics-15-00582-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/efb48235ed4a/diagnostics-15-00582-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/130fb1f5fdcd/diagnostics-15-00582-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57ea/11899611/e0c36849f729/diagnostics-15-00582-g009.jpg

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Deep learning assessment of senescence-associated nuclear morphologies in mammary tissue from healthy female donors to predict future risk of breast cancer: a retrospective cohort study.对健康女性捐赠者乳腺组织中衰老相关核形态进行深度学习评估以预测未来患乳腺癌风险:一项回顾性队列研究
Lancet Digit Health. 2024 Oct;6(10):e681-e690. doi: 10.1016/S2589-7500(24)00150-X.
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Deep learning empowered breast cancer diagnosis: Advancements in detection and classification.
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