Hsu Chou-Yi, Kanjariya Prakash, Ariffin I A, Rajiv Asha, Kashyap Aditya, Jebaselvi G D Anbarasi, Choudhury Satish, Yadav Yashpal, Rao P Sankara, Shah Sanjeev Kumar, Pal Amrindra
Thunderbird School of Global Management, Arizona State University, Tempe Campus, Phoenix, AZ, 85004, USA.
Marwadi University Research Center, Department of Physics, Faculty of Science, Marwadi University, Rajkot, Gujarat, India.
Mikrochim Acta. 2025 Apr 16;192(5):302. doi: 10.1007/s00604-025-07161-6.
A novel surface plasmon resonance (SPR) biosensor design for point-of-care detection of different bacteria is presented. It consists of a SiO prism, metal (Ag), silicon carbide (SiC), 2D materials of zirconium nitride (ZrN), and a sensing medium. The proposed structure's angular reflectivity is investigated using the transfer matrix method (TMM) following optimization of the Ag and SiC layer thicknesses. For the various types of bacteria such as Staphylococcus (S) aureus, faecalis 9790, aureus Duncan, and aureus 52A5, the maximal sensitivity of 327, 362.45, 301.46, and 269.87°/RIU is achieved with remarkable minimum reflectance (R). According to simulation results, using a new class of 2D materials significantly improves the sensor performance over the conventional SPR configuration. Furthermore, the proposed SPR structure is presented with COMSOL Multiphysics to measure the electric field enhancement factor and intensity close to the ZrN material-sensing layer interface. Using the fabrication technologies to fabricate the proposed sensor as an SPR chip is worthwhile due to its real-time and label-free detection of malaria diseases.
本文提出了一种用于即时检测不同细菌的新型表面等离子体共振（SPR）生物传感器设计。它由一个SiO棱镜、金属（Ag）、碳化硅（SiC）、氮化锆（ZrN）二维材料和一个传感介质组成。在优化Ag和SiC层厚度后，采用传输矩阵法（TMM）研究了所提出结构的角反射率。对于金黄色葡萄球菌、粪肠球菌9790、邓肯金黄色葡萄球菌和金黄色葡萄球菌52A5等不同类型的细菌，在显著的最小反射率（R）下实现了327、362.45、301.46和269.87°/RIU的最大灵敏度。根据模拟结果，使用新型二维材料比传统SPR配置显著提高了传感器性能。此外，利用COMSOL Multiphysics展示了所提出的SPR结构，以测量靠近ZrN材料传感层界面的电场增强因子和强度。由于其对疟疾疾病的实时无标记检测，利用制造技术将所提出的传感器制作为SPR芯片是值得的。
