抑制性和辅助性T细胞诱导过程中的T-T相互作用：前体细胞和放大细胞的膜表型分析
T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells.
作者信息
Feldmann M, Beverley P C, Woody J, McKenzie I F
出版信息
J Exp Med. 1977 Apr 1;145(4):793-801. doi: 10.1084/jem.145.4.793.
Abstract
The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly-1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-.
摘要
确定了参与体外辅助细胞和抑制细胞生成的T淋巴细胞的Ly和Ia表型。两种细胞的前体均存在于成年去胸腺脾脏中。辅助细胞前体为Ly-1+2-3-Ia-，而抑制细胞前体为Ly-1-2+3+Ia-，尽管抑制效应细胞为Ia+。在这两种情况下，前体细胞的分化都需要第二种“放大”细胞。这种细胞存在于抗淋巴细胞血清处理过的脾脏中，其表型为Ly-1+2+3+Ia-。
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本文引用的文献
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J Exp Med. 1969 Mar 1;129(3):591-603. doi: 10.1084/jem.129.3.591.
2
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J Immunol. 1974 Jul;113(1):27-38.
3
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J Exp Med. 1972 Apr 1;135(4):938-55. doi: 10.1084/jem.135.4.938.
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