Vesey C J, Saloojee Y, Cole P V, Russell M A
Br Med J (Clin Res Ed). 1982 May 22;284(6328):1516-8. doi: 10.1136/bmj.284.6328.1516.
Carboxyhaemoglobin and plasma thiocyanate concentrations were found to be significantly correlated with self-reported daily cigarette consumption in 360 smokers (r = 0.416 and 0.412 respectively; p less than 0.001). The extent to which inhalation patterns affected the intake of cigarette smoke constituents was determined from the partial correlation between carboxyhaemoglobin and plasma thiocyanate concentrations after the number of cigarettes smoke per day had been allowed for (r = 0.48). Thus 23% of the variation in carboxyhaemoglobin and thiocyanate concentrations was accounted for by the was a cigarette was smoked and a further 21% by the number smoked a day. Furthermore, the relation between carboxyhaemoglobin or plasma thiocyanate and daily cigarette consumption was not linear but reached an asymptote at consumption rates above 25 cigarettes a day. These results suggest that by itself daily cigarette consumption will not identify those smokers most at risk and will also underestimate and dose-response relationship between smoking and selected diseases.
在360名吸烟者中，发现碳氧血红蛋白和血浆硫氰酸盐浓度与自我报告的每日吸烟量显著相关（分别为r = 0.416和0.412；p < 0.001）。在考虑每日吸烟支数后，通过碳氧血红蛋白和血浆硫氰酸盐浓度之间的偏相关来确定吸入模式对香烟烟雾成分摄入量的影响程度（r = 0.48）。因此，碳氧血红蛋白和硫氰酸盐浓度变化的23%可由吸烟方式解释，另外21%可由每日吸烟支数解释。此外，碳氧血红蛋白或血浆硫氰酸盐与每日吸烟量之间的关系并非线性，在每日吸烟量超过25支时达到渐近线。这些结果表明，仅通过每日吸烟量本身无法识别那些风险最高的吸烟者，并且还会低估吸烟与某些疾病之间的剂量反应关系。
