用于脱氧多核苷酸合成的颜色编码三芳基甲基保护基团。
Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis.
作者信息
Fisher E F, Caruthers M H
出版信息
Nucleic Acids Res. 1983 Mar 11;11(5):1589-99. doi: 10.1093/nar/11.5.1589.
Abstract
Triarylmethyl groups having different colors but similar chemical reactivities in acid were examined as potential aids for monitoring the stepwise addition of mononucleotides to a deoxyoligonucleotide. The successful application of these protecting groups to deoxyoligonucleotide synthesis on polymer supports was demonstrated.
摘要
对在酸性条件下具有不同颜色但化学反应活性相似的三芳基甲基进行了研究，以作为监测单核苷酸逐步添加到脱氧寡核苷酸过程中的潜在辅助手段。结果表明这些保护基团在聚合物载体上的脱氧寡核苷酸合成中得到了成功应用。
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本文引用的文献
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2
Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.寡脱氧核糖核苷酸的快速合成。IV. 通过磷酸三酯中间体改进寡脱氧核糖核苷酸的固相合成
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Nucleic Acids Res. 1982 Aug 11;10(15):4671-8. doi: 10.1093/nar/10.15.4671.
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