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1
Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis.用于脱氧多核苷酸合成的颜色编码三芳基甲基保护基团。
Nucleic Acids Res. 1983 Mar 11;11(5):1589-99. doi: 10.1093/nar/11.5.1589.
2
Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method.多核苷酸的固相合成。II. 用片段偶联磷酸三酯法合成聚胸腺嘧啶核苷酸
Nucleic Acids Res. 1980 Nov 25;8(22):5473-89. doi: 10.1093/nar/8.22.5473.
3
Synthesis and physicochemical properties of two analogs of poly(dA): poly(2-aminopurine-9-beta-D-deoxyribonucleotide) and poly 2-amino-deoxyadenylic acid.聚（dA）的两种类似物的合成及物理化学性质：聚（2-氨基嘌呤-9-β-D-脱氧核糖核苷酸）和聚2-氨基脱氧腺苷酸。
Nucleic Acids Res. 1982 Jul 10;10(13):4059-69. doi: 10.1093/nar/10.13.4059.
4
Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 2. Chemical synthesis of the deoxypolynucleotide segments corresponding to the nucleotide sequence 1-31.
J Biol Chem. 1976 Feb 10;251(3):571-86.
5
Synthesis of oligonucleotides containing the hypermodified base, alpha-putrescinylthymine.含超修饰碱基α-腐胺基胸腺嘧啶的寡核苷酸的合成
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6
Solid-phase synthesis of polynucleotides. IV. Usage of polystyrene resins for the synthesis of polydeoxyribonucleotides by the phosphostriester method.多核苷酸的固相合成。IV. 磷酸三酯法中聚苯乙烯树脂在聚脱氧核糖核苷酸合成中的应用。
Nucleic Acids Res. 1980 Nov 25;8(22):5507-17. doi: 10.1093/nar/8.22.5507.
7
Solid-phase synthesis of polynucleotides. III. Synthesis of polynucleotides with defined sequences by the block coupling phosphotriester method.多核苷酸的固相合成。III. 用片段偶联磷酸三酯法合成具有特定序列的多核苷酸。
Nucleic Acids Res. 1980 Nov 25;8(22):5491-505. doi: 10.1093/nar/8.22.5491.
8
Synthesis of deoxypolynucleotides interacting with proteins: large scale synthesis of lambda OR3 17 mer and CAP site 21 mer duplexes by 3'-phosphoro-p-anisidate method.与蛋白质相互作用的脱氧多核苷酸的合成：通过3'-对茴香酸磷酸酯法大规模合成λ OR3 17聚体和CAP位点21聚体双链体
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A new condensing reagent, 1-(2,4,6-triisopropylbenzenesulfonyl)-5-(pyridin-2-yl)tetrazolide and its use in the synthesis of lambda cro binding heptadecanucleotide on a polymer support.一种新型缩合试剂，1-(2,4,6-三异丙基苯磺酰基)-5-(吡啶-2-基)四唑化物及其在聚合物载体上合成λ cro结合十七聚核苷酸中的应用。
Nucleic Acids Res. 1982 Oct 25;10(20):6235-41. doi: 10.1093/nar/10.20.6235.
10
New chemical methods for synthesizing polynucleotides.合成多核苷酸的新化学方法。
Nucleic Acids Symp Ser. 1980(7):215-23.

引用本文的文献

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Aromatic or Hetero-aromatic Directly Attached Tri and Tetrasubstituted Methanes: New Chemical Entities as Anti-Infectives.芳族或杂芳族直接连接的三取代和四取代甲烷：作为抗感染剂的新化学实体。
Curr Med Chem. 2023;30(8):974-998. doi: 10.2174/0929867329666220823111812.
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1,N6-etheno deoxy and ribo adenosine and 3,N4-etheno deoxy and ribo cytidine phosphoramidites. Strongly fluorescent structures for selective introduction in defined sequence DNA and RNA molecules.1,N6-乙撑脱氧和核糖腺苷以及3,N4-乙撑脱氧和核糖胞苷亚磷酰胺。用于以特定序列选择性引入DNA和RNA分子的强荧光结构。
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4
Mass spectrometric monitoring of solid phase phosphate triester synthesis of DNA fragments.DNA片段固相磷酸三酯合成的质谱监测
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5
Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis.具有新型修饰的短寡脱氧核苷酸的合成与生物物理研究：解决混合碱基寡脱氧核苷酸合成问题的一种可能方法。
Nucleic Acids Res. 1984 Oct 11;12(19):7435-53. doi: 10.1093/nar/12.19.7435.
6
Analytical studies of 'mixed sequence' oligodeoxyribonucleotides synthesized by competitive coupling of either methyl- or beta-cyanoethyl-N,N-diisopropylamino phosphoramidite reagents, including 2'-deoxyinosine.对通过甲基或β-氰基乙基-N,N-二异丙基氨基亚磷酰胺试剂（包括2'-脱氧次黄苷）的竞争性偶联合成的“混合序列”寡脱氧核糖核苷酸的分析研究。
Nucleic Acids Res. 1985 Nov 25;13(22):8181-96. doi: 10.1093/nar/13.22.8181.
7
Modified oligonucleotides as alternatives to the synthesis of mixed probes for the screening of cDNA libraries.修饰寡核苷酸作为合成混合探针用于筛选cDNA文库的替代方法。
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7510-4. doi: 10.1073/pnas.82.22.7510.

本文引用的文献

1
DNA sequence analysis: a general, simple and rapid method for sequencing large oligodeoxyribonucleotide fragments by mapping.DNA序列分析：一种通过图谱对大的寡脱氧核糖核苷酸片段进行测序的通用、简单且快速的方法。
Nucleic Acids Res. 1974 Mar;1(3):331-53. doi: 10.1093/nar/1.3.331.
2
Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.寡脱氧核糖核苷酸的快速合成。IV. 通过磷酸三酯中间体改进寡脱氧核糖核苷酸的固相合成
Nucleic Acids Res. 1980 Mar 11;8(5):1081-96. doi: 10.1093/nar/8.5.1081.
3
Ultrafast sequencing of oligodeoxyribonucleotides by FAB-mass spectrometry.用快原子轰击质谱法对寡脱氧核糖核苷酸进行超快测序
Nucleic Acids Res. 1982 Aug 11;10(15):4671-8. doi: 10.1093/nar/10.15.4671.
4
Recent developments in the chemical synthesis of polynucleotides.多核苷酸化学合成的最新进展。
Nucleic Acids Res. 1982 Nov 11;10(21):6553-70. doi: 10.1093/nar/10.21.6553.
5
Synthesis of oligodeoxyribonucleotides on silica gel support.硅胶载体上寡脱氧核糖核苷酸的合成。
Nucleic Acids Res. 1981 Jun 25;9(12):2807-17. doi: 10.1093/nar/9.12.2807.

用于脱氧多核苷酸合成的颜色编码三芳基甲基保护基团。

Color coded triarylmethyl protecting groups useful for deoxypolynucleotide synthesis.

作者信息

Fisher E F, Caruthers M H

出版信息

Nucleic Acids Res. 1983 Mar 11;11(5):1589-99. doi: 10.1093/nar/11.5.1589.

DOI:10.1093/nar/11.5.1589
PMID:6828388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC325818/
Abstract

Triarylmethyl groups having different colors but similar chemical reactivities in acid were examined as potential aids for monitoring the stepwise addition of mononucleotides to a deoxyoligonucleotide. The successful application of these protecting groups to deoxyoligonucleotide synthesis on polymer supports was demonstrated.

摘要

对在酸性条件下具有不同颜色但化学反应活性相似的三芳基甲基进行了研究，以作为监测单核苷酸逐步添加到脱氧寡核苷酸过程中的潜在辅助手段。结果表明这些保护基团在聚合物载体上的脱氧寡核苷酸合成中得到了成功应用。