Hand A R
J Histochem Cytochem. 1980 Jan;28(1):82-6. doi: 10.1177/28.1.7351475.
GERL exhibits a number of structural properties, such as its location at the trans face of the Golgi apparatus, thick limiting membranes with occasional coated regions, and close relationship to the ER, which are similar in all cells wehre it has been identified. Acid hydrolase activity and the formation of lysosomes, also considered characteristic of GERL, have been shown to be less consistent properties of GERL in some cells. Finally, GERL and the Golgi saccules of certain cells undergo significant changes in their cytochemical and structural properties in response to specific alterations in cellular activity. These variations are important for at least two reasons: first, they indicate the care required in differentiating GERL from the Golgi saccules based on limited cytochemical observations; second, and most important, they may yield information regarding the biogenetic and functional relationships between the ER, Golgi saccules, and GERL, such as the origin of GERL in various cells and the role of each organelle in the processing of lysosomal and secretory proteins.
GERL具有许多结构特性，比如它位于高尔基体反面，有较厚的限制膜且偶尔有被膜区域，并且与内质网关系密切，在所有已发现它的细胞中这些特性都是相似的。酸性水解酶活性和溶酶体的形成，虽然也被认为是GERL的特征，但在某些细胞中已显示出GERL的这些特性不太一致。最后，某些细胞的GERL和高尔基体囊泡在细胞活动发生特定改变时，其细胞化学和结构特性会发生显著变化。这些变化至少有两个重要原因：第一，它们表明基于有限的细胞化学观察来区分GERL和高尔基体囊泡时需要谨慎；第二，也是最重要的，它们可能会提供有关内质网、高尔基体囊泡和GERL之间生物发生和功能关系的信息，比如GERL在各种细胞中的起源以及每个细胞器在溶酶体和分泌蛋白加工过程中的作用。
