Kawano Y, Kira J
Department of Neurology, Faculty of Medicine, Kyushu University 60, Fukuoka, Japan.
J Neurol Neurosurg Psychiatry. 1995 Oct;59(4):435-7. doi: 10.1136/jnnp.59.4.435.
Two patients presenting with recurrent multiple cranial neuropathy showed diffuse thickening and gadolinium enhancement of the dura mater on brain MRI. Both had anti-HTLV-I antibodies in serum. A quantitative polymerase chain reaction study of the peripheral blood disclosed that the HTLV-I proviral DNA loads increased considerably in one case and moderately in the other. Both showed a spontaneous proliferation of peripheral blood lymphocytes as well as an increase in helper/inducer T cells. Neither had any other underlying infections or autoimmune diseases. Thus it is possible that hypertrophic pachymeningitis developed as a result of multiorgan involvement of HTLV-I infection in these patients.
两名表现为复发性多发性颅神经病变的患者在脑部磁共振成像（MRI）上显示硬脑膜弥漫性增厚且钆增强。两人血清中均有抗人类嗜T淋巴细胞病毒I型（HTLV-I）抗体。对外周血进行的定量聚合酶链反应研究表明，其中一例患者的HTLV-I前病毒DNA载量大幅增加，另一例则中度增加。两人均表现为外周血淋巴细胞自发增殖以及辅助/诱导性T细胞增多。两人均无其他潜在感染或自身免疫性疾病。因此，在这些患者中，肥厚性硬脑膜炎有可能是由HTLV-I感染的多器官累及所致。
