Winter C G, Saotome Y, Levison S W, Hirsh D
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5865-9. doi: 10.1073/pnas.92.13.5865.
Within the central nervous system (CNS) ciliary neurotrophic factor (CNTF) is expressed by astrocytes where it remains stored as an intracellular protein; its release and function as an extracellular ligand are thought to occur in the event of cellular injury. We find that overexpression of CNTF in transgenic mice recapitulates the glial response to CNS lesion, as does its injection into the uninjured brain. These results demonstrate that CNTF functions as an inducer of reactive gliosis, a condition associated with a number of neurological diseases of the CNS.
在中枢神经系统（CNS）中，睫状神经营养因子（CNTF）由星形胶质细胞表达，并作为一种细胞内蛋白储存于其中；其释放及作为细胞外配体的功能被认为发生在细胞损伤时。我们发现，在转基因小鼠中CNTF的过表达重现了对CNS损伤的神经胶质反应，将其注射到未受伤的大脑中时也是如此。这些结果表明，CNTF作为反应性胶质增生的诱导剂发挥作用，反应性胶质增生是一种与多种CNS神经疾病相关的病症。
