Van Ewijk P H, Hoekstra J A
Solvay Duphar BV, Weesp, The Netherlands.
Ecotoxicol Environ Saf. 1993 Feb;25(1):25-32. doi: 10.1006/eesa.1993.1003.
In many experiments in toxicology and ecotoxicology with continuous response, like growth, a stimulus is found for low doses, while higher doses are toxic. This subtoxic stimulus is called hormesis. The standard logistic model cannot be used when hormesis occurs. A model is given which can describe this phenomenon. The model has the EC50 as one of its parameters. This has the advantage that the EC50 and its confidence interval can be determined directly by nonlinear regression. Also, the tests for the presence of hormesis and lack of fit are described.
在毒理学和生态毒理学中许多具有连续响应（如生长）的实验里，低剂量时会发现一种刺激作用，而高剂量则具有毒性。这种亚毒性刺激被称为兴奋效应。当出现兴奋效应时，标准逻辑斯蒂模型无法使用。给出了一个能够描述这种现象的模型。该模型将半数效应浓度（EC50）作为其参数之一。这样做的优点是，EC50及其置信区间可通过非线性回归直接确定。此外，还描述了兴奋效应存在与否以及拟合不足的检验方法。
