Dorant E, van den Brandt P A, Goldbohm R A
Department of Epidemiology, University of Limburg, Maastricht, The Netherlands.
Breast Cancer Res Treat. 1995;33(2):163-70. doi: 10.1007/BF00682723.
The risk of female breast carcinoma in relation to onion and leek consumption and the use of garlic supplements was evaluated in the Netherlands Cohort Study on diet and cancer. Onions, leeks, and garlic contain specific compounds which might act as antimutagens. Animal experiments also suggest a possible role for these compounds in inhibition of mammary carcinogenesis. The Netherlands Cohort Study was started in 1986 among 120,852 Dutch men and women, aged 55-69 years, with collecting information on usual diet and important lifestyle characteristics. After 3.3 years of follow-up, 469 incident female breast carcinoma cases and 1713 female members of a randomly sampled control subcohort were available for analysis. Intake of onions or leeks was not associated with breast carcinoma risk after controlling for dietary and nondietary risk factors: the rate ratios in the highest intake categories were 0.95 (95% confidence interval 0.61-1.47) and 1.08 (95% confidence interval 0.79-1.48), respectively, compared with the lowest intake categories. The tests for trend in the rate ratios were neither significant. Garlic supplement use was also not associated with breast carcinoma incidence (rate ratio = 0.87, 95% confidence interval 0.58-1.31). In conclusion, we found no association between the consumption of onions or leeks, or garlic supplement use, and the incidence of female breast carcinoma.
在荷兰饮食与癌症队列研究中，评估了食用洋葱和韭菜以及使用大蒜补充剂与女性患乳腺癌风险之间的关系。洋葱、韭菜和大蒜含有特定化合物，这些化合物可能具有抗诱变作用。动物实验也表明这些化合物在抑制乳腺癌发生过程中可能发挥作用。荷兰队列研究始于1986年，研究对象为120,852名年龄在55至69岁之间的荷兰男性和女性，收集了他们的日常饮食和重要生活方式特征信息。经过3.3年的随访，有469例女性乳腺癌新发病例和1713名随机抽样的对照亚队列女性成员可供分析。在控制了饮食和非饮食风险因素后，洋葱或韭菜的摄入量与乳腺癌风险无关：与最低摄入量类别相比，最高摄入量类别的率比分别为0.95（95%置信区间0.61 - 1.47）和1.08（95%置信区间0.79 - 1.48）。率比的趋势检验也均无显著性。使用大蒜补充剂也与乳腺癌发病率无关（率比 = 0.87，95%置信区间0.58 - 1.31）。总之，我们发现食用洋葱或韭菜、使用大蒜补充剂与女性乳腺癌发病率之间无关联。
