Nakamura N, Shidara Y, Kawaguchi N, Azuma C, Mitsuda N, Onishi S, Yamaji K, Wada Y
Osaka Medical Center, Japan.
Biochem Biophys Res Commun. 1994 Dec 15;205(2):1488-93. doi: 10.1006/bbrc.1994.2833.
The effects of lupus anticoagulant (LAC) on cultured human umbilical vein endothelial cells were studied. All five monoclonal antibodies from a patient with systemic lupus erythematosus (SLE), as well as plasma samples with LAC activity from six SLE patients, induced apoptosis. Anti-annexin V IgG also induced apoptosis. Since monoclonal antibodies and plasma from SLE patients had an affinity for annexin V, an endothelial apoptosis pathway mediated by annexin V was suggested as the molecular pathogenesis of the hemostatic derangement associated with LAC.
研究了狼疮抗凝物（LAC）对培养的人脐静脉内皮细胞的影响。来自一名系统性红斑狼疮（SLE）患者的所有五种单克隆抗体，以及来自六名SLE患者的具有LAC活性的血浆样本，均诱导细胞凋亡。抗膜联蛋白V IgG也诱导细胞凋亡。由于SLE患者的单克隆抗体和血浆对膜联蛋白V具有亲和力，因此提示由膜联蛋白V介导的内皮细胞凋亡途径是与LAC相关的止血紊乱的分子发病机制。
