Poinoosawmy D, Fontana L, Wu J X, Fitzke F W, Hitchings R A
Glaucoma Unit, Moorfields Eye Hospital, London.
Br J Ophthalmol. 1997 May;81(5):350-4. doi: 10.1136/bjo.81.5.350.
Scanning laser polarimetry is a new technique allowing quantitative analysis of the retinal nerve fibre layer in vivo. This technique was employed to investigate the variation of the retinal nerve fibre layer thickness in a group of normal subjects of different ages and ethnic groups.
150 normal volunteers of different ages and ethnic groups were recruited for this study. Three consecutive 15-degree polarimetric maps were acquired for each subjects. Nerve fibre layer thickness measurements were obtained at 1.5 disc diameters from the optic nerve. Four 90-degree quadrants were identified.
The mean nerve fibre layer thickness varied from a minimum of 55.4 microns to a maximum of 105.3 microns, with a mean thickness value of 78.2 (SD 10.6) microns. Superior and inferior quadrants showed a comparatively thicker nerve fibre layer than nasal and temporal quadrants. Retinal nerve fibre layer thickness is inversely correlated with age (p < 0.001). White people showed thicker nerve fibre layers than Afro-Caribbeans (p = 0.002).
The results indicate a progressive reduction of the nerve fibre layer thickness with increasing age. This may be due to a progressive loss of ganglion axons with age as suggested in postmortem studies. A racial difference in nerve fibre layer thickness is present between whites and Afro-Caribbeans.
扫描激光偏振imetry是一种允许对视网膜神经纤维层进行体内定量分析的新技术。该技术用于研究一组不同年龄和种族的正常受试者视网膜神经纤维层厚度的变化。
招募了150名不同年龄和种族的正常志愿者进行本研究。为每个受试者获取连续三张15度的偏振图。在距视神经1.5个视盘直径处测量神经纤维层厚度。确定了四个90度象限。
神经纤维层平均厚度从最小值55.4微米到最大值105.3微米不等，平均厚度值为78.2（标准差10.6）微米。上象限和下象限的神经纤维层比鼻侧象限和颞侧象限相对更厚。视网膜神经纤维层厚度与年龄呈负相关（p < 0.001）。白人的神经纤维层比非裔加勒比人厚（p = 0.002）。
结果表明神经纤维层厚度随年龄增长而逐渐降低。这可能如死后研究中所提示的，是由于随着年龄增长神经节轴突逐渐丧失。白人和非裔加勒比人之间存在神经纤维层厚度的种族差异。
