2000年至2005年在斯洛文尼亚收集的产超广谱β-内酰胺酶的克雷伯菌分离株中喹诺酮耐药介导基因aac(6')-Ib-cr的出现。
Emergence of the quinolone resistance-mediating gene aac(6')-Ib-cr in extended-spectrum-beta-lactamase-producing Klebsiella isolates collected in Slovenia between 2000 and 2005.
作者信息
Ambrozic Avgustin Jerneja, Keber Rok, Zerjavic Katja, Orazem Toni, Grabnar Miklavz
机构信息
Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia.
出版信息
Antimicrob Agents Chemother. 2007 Nov;51(11):4171-3. doi: 10.1128/AAC.01480-06. Epub 2007 Sep 10.
Abstract
Seventy-four nonrepetitive uropathogenic fluoroquinolone-resistant or -intermediate extended-spectrum-beta-lactamase-producing Klebsiella isolates from Slovenia were screened for the presence of plasmid-mediated quinolone resistance genes. None of the known qnr genes were detected. The aac(6')-Ib-cr allele was detected on plasmids from 25 transconjugants for which the ciprofloxacin MIC was higher than for the recipient Escherichia coli strain.
摘要
对来自斯洛文尼亚的74株非重复性产超广谱β-内酰胺酶的耐氟喹诺酮或氟喹诺酮中介的尿路致病性克雷伯菌分离株进行了质粒介导喹诺酮耐药基因的筛查。未检测到任何已知的qnr基因。在25个转接合子的质粒上检测到aac(6')-Ib-cr等位基因，这些转接合子的环丙沙星最低抑菌浓度高于受体大肠杆菌菌株。
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