Badiu Diana L, Balu Alina M, Barbes Lucica, Luque Rafael, Nita Roxana, Radu Marius, Tanase Ecaterina, Rosoiu Natalia
Department of Biology-Biochemistry, Faculty of Natural and Agricultural Sciences, Ovidius University of Constanza, Constanza, Romania.
Lipids. 2008 Sep;43(9):829-41. doi: 10.1007/s11745-008-3205-2. Epub 2008 Jul 10.
Black Sea molluscs and gastropods are the most studied organisms from the Romanian littoral zone. In particular, those from the Mytilidae species are of great interest because biochemical investigations have shown that they can be sources of biological active substances which can have different applications (e.g. food additives). We report here the extraction of lipids from two different species of molluscs (Mytilus galloprovincialis L., Mediterranean mussel) and gastropods (Rapana venosa, hard-shell clam). The extracts were evaluated in terms of antioxidant and composition properties and their healing properties were tested on skin burns in Wistar rats. Our studies proved that the two lipid extracts contained a relatively complex distribution of compounds, in terms of characteristic indices, polyunsaturated fatty acids (PUFA) and vitamins E and D. The presence of such compounds rendered the extracts very efficient in healing induced skin burns in Wistar rats. The histological analysis showed a reduction in the time of healing (12-13 and 13-15 days for the Mytilus galloprovincialis (L.) Rapana venosa extracts, respectively) compared to 20-22 for untreated animals, based on results from tissues and blood samples. Our investigations have been proved to be promising in terms of future potential applications of the extracts as skin-care products, cosmetics and/or pharmaceutical preparations owing to their dermorestitutive properties.
黑海软体动物和腹足纲动物是罗马尼亚沿海地区研究最多的生物。特别是贻贝科的那些物种，因为生化研究表明它们可能是具有不同应用（如食品添加剂）的生物活性物质的来源，所以备受关注。我们在此报告从两种不同的软体动物（地中海贻贝，即加利福尼亚贻贝）和腹足纲动物（疣荔枝螺，即硬壳蛤）中提取脂质的情况。对提取物的抗氧化和成分特性进行了评估，并在Wistar大鼠的皮肤烧伤上测试了它们的愈合特性。我们的研究证明，就特征指数、多不饱和脂肪酸（PUFA）以及维生素E和D而言，这两种脂质提取物含有相对复杂的化合物分布。这些化合物的存在使提取物在治愈Wistar大鼠的诱导皮肤烧伤方面非常有效。组织学分析表明，与未处理动物的20 - 22天相比，愈合时间有所缩短（加利福尼亚贻贝提取物为12 - 13天，疣荔枝螺提取物为13 - 15天），这是基于组织和血液样本的结果得出的。由于提取物具有皮肤修复特性，我们的研究已被证明在提取物作为护肤品、化妆品和/或药物制剂的未来潜在应用方面很有前景。
