McClintock P R, Ihle J N, Joseph D R
J Exp Med. 1977 Aug 1;146(2):422-34. doi: 10.1084/jem.146.2.422.
By competition radioimmune assays with antisera against AKR murine leukemia virus (MuLV) gp 71 or antisera against xenotropic virus, and iodinated AKR MuLV gp71 or BALB(X) gp71, antigens serologically indistinguishable from the viral antigens can be detected in tissues of normal mice in the absence of overt virus expression. An antigen serologically indistinguishable from AKR MuLV gp71 can be readily detected in normal bone marrow cells of the common strains of mice including NIH Swiss, 129/J, and SWR/J, as well as in Mus cervicolor and Mus musculus casteneus. In contrast, this antigen is not detected in normal spleen, thymus, lymph nodes, or serum. Similarly, an antigen serologically indistinguishable from BALB(X) gp71 was found in all normal mouse sera examined. This antigen was not present in fetal liver, perfused adult liver, thymus, spleen, lymph nodes, or bone marrow of the mice examined. An equivalent antigen was detected in sera from Mus musculus casteneus but not in sera from Mus cervicolor.
通过使用抗AKR小鼠白血病病毒（MuLV）gp71的抗血清或抗嗜异性病毒的抗血清进行竞争性放射免疫测定，以及碘化的AKR MuLV gp71或BALB(X) gp71，可以在正常小鼠组织中检测到与病毒抗原在血清学上无法区分的抗原，而此时并无明显的病毒表达。在包括NIH瑞士小鼠、129/J和SWR/J在内的常见小鼠品系的正常骨髓细胞中，以及在黍色姬鼠和斯氏小家鼠中，都能很容易地检测到一种在血清学上与AKR MuLV gp71无法区分的抗原。相比之下，在正常脾脏、胸腺、淋巴结或血清中未检测到这种抗原。同样，在所检测的所有正常小鼠血清中都发现了一种在血清学上与BALB(X) gp71无法区分的抗原。在所检测的小鼠的胎儿肝脏、灌注的成年肝脏、胸腺、脾脏、淋巴结或骨髓中均不存在这种抗原。在斯氏小家鼠的血清中检测到了一种等效抗原，但在黍色姬鼠的血清中未检测到。
