草莓可降低代谢综合征患者的动脉粥样硬化标志物。
Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.
机构信息
Nutritional Sciences, 301 Human Environmental Sciences, Oklahoma State University, Stillwater, OK 74078-6141, USA.
出版信息
Nutr Res. 2010 Jul;30(7):462-9. doi: 10.1016/j.nutres.2010.06.016.
Strawberries have been reported to be potent antioxidants and reduce cardiovascular risk factors, such as elevated blood pressure, hyperglycemia, dyslipidemia, and inflammation in limited studies. We hypothesized that freeze-dried strawberry supplementation will improve blood pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome, thereby lowering cardiovascular risk factors in these subjects. Twenty-seven subjects with metabolic syndrome (2 males and 25 females; body mass index, 37.5 +/- 2.15 kg/m(2); age, 47.0 +/- 3.0 years [means +/- SE]) consumed 4 cups of freeze-dried strawberry beverage (50 g freeze-dried strawberries approximately 3 cups fresh strawberries) or equivalent amounts of fluids (controls, 4 cups of water) daily for 8 weeks in a randomized controlled trial. Anthropometrics and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screen and 8 weeks of the study. Strawberry supplementation significantly decreased total and low-density lipoprotein cholesterol (5.8 +/- 0.2 to 5.2 +/- 0.2 mmol/L and 3.5 +/- 0.2 to 3.1 +/- 0.1 mmol/L, respectively [means +/- SE], P < .05) and small low-density lipoprotein particles using nuclear magnetic resonance-determined lipoprotein subclass profile vs controls at 8 weeks (794.6 +/- 94.0 to 681.8 +/- 86.0 nmol/L [means +/- SE], P < .05). Strawberry supplementation further decreased circulating levels of vascular cell adhesion molecule-1 vs controls at 8 weeks (272.7 +/- 17.4 to 223.0 +/- 14.0 ng/mL [means +/- SE], P < .05). Serum glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, and waist circumference were not affected. Thus, short-term freeze-dried strawberry supplementation improved selected atherosclerotic risk factors, including dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome, and these results need confirmation in future trials.
草莓已被报道具有很强的抗氧化作用，并能降低心血管危险因素，如高血压、高血糖、血脂异常和炎症，这些作用在有限的研究中得到了证实。我们假设，冻干草莓补充剂将改善代谢综合征患者的血压、葡萄糖受损、血脂异常或循环黏附分子，从而降低这些患者的心血管危险因素。27 名代谢综合征患者（2 名男性和 25 名女性；体重指数，37.5 +/- 2.15 kg/m(2)；年龄，47.0 +/- 3.0 岁[平均值 +/- SE]）在一项随机对照试验中每天摄入 4 杯冻干草莓饮料（约 50 克冻干草莓相当于 3 杯新鲜草莓）或等量的液体（对照组，4 杯水），持续 8 周。在研究的第 8 周和筛查时进行人体测量和血压测量、饮食摄入评估和空腹采血。与对照组相比，草莓补充剂在 8 周时显著降低了总胆固醇和低密度脂蛋白胆固醇（5.8 +/- 0.2 至 5.2 +/- 0.2 mmol/L 和 3.5 +/- 0.2 至 3.1 +/- 0.1 mmol/L，平均值 +/- SE，P <.05）和小而密的低密度脂蛋白颗粒，使用磁共振确定的脂蛋白亚类谱（794.6 +/- 94.0 至 681.8 +/- 86.0 nmol/L [平均值 +/- SE]，P <.05）。草莓补充剂还进一步降低了循环血管细胞黏附分子-1 的水平，与对照组相比，在 8 周时（272.7 +/- 17.4 至 223.0 +/- 14.0 ng/mL [平均值 +/- SE]，P <.05）。血清葡萄糖、甘油三酯、高密度脂蛋白胆固醇、血压和腰围没有受到影响。因此，短期冻干草莓补充剂改善了代谢综合征患者的某些动脉粥样硬化危险因素，包括血脂异常和循环黏附分子，这些结果需要在未来的试验中得到证实。
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