Shapiro Benjamin, Dormer Kenneth, Rutel Isaac B
Fischell Department of Bio-Engineering, Institute for Systems Research (ISR), 1226 Kim Building, University of Maryland, College Park, MD 20742.
AIP Conf Proc. 2010 Dec 1;1311(1):77-88. doi: 10.1063/1.3530064.
Magnetic fields can be used to direct magnetically susceptible nanoparticles to disease locations: to infections, blood clots, or tumors. Any single magnet always attracts (pulls) ferro- or para-magnetic particles towards it. External magnets have been used to pull therapeutics into tumors near the skin in animals and human clinical trials. Implanting magnetic materials into patients (a feasible approach in some cases) has been envisioned as a means of reaching deeper targets. Yet there are a number of clinical needs, ranging from treatments of the inner ear, to antibiotic-resistant skin infections and cardiac arrhythmias, which would benefit from an ability to magnetically "inject", or push in, nanomedicines. We develop, analyze, and experimentally demonstrate a novel, simple, and effective arrangement of just two permanent magnets that can magnetically push particles. Such a system might treat diseases of the inner ear; diseases which intravenously injected or orally administered treatments cannot reach due to the blood-brain barrier.
感染处、血栓或肿瘤。任何单个磁体总会将铁磁性或顺磁性颗粒吸引（拉）向它。在动物和人体临床试验中，外部磁体已被用于将治疗剂拉至皮肤附近的肿瘤中。将磁性材料植入患者体内（在某些情况下是一种可行的方法）已被设想为一种到达更深层靶点的手段。然而，从内耳治疗到耐抗生素皮肤感染和心律失常等，有许多临床需求将受益于磁性“注射”或推进纳米药物的能力。我们开发、分析并通过实验证明了一种仅由两个永磁体组成的新颖、简单且有效的排列方式，该排列方式能够磁性推动颗粒。这样的系统可能用于治疗内耳疾病；由于血脑屏障，静脉注射或口服治疗无法到达的疾病。
