牛痘病毒对化学消毒剂的敏感性。
Susceptibility of Vaccinia virus to chemical disinfectants.
机构信息
Laboratório de Pesquisa em Virologia Animal, Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, e Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Am J Trop Med Hyg. 2011 Jul;85(1):152-7. doi: 10.4269/ajtmh.2011.11-0144.
Vaccinia virus (VACV) is the cause of bovine vaccinia (BV), an emerging zoonotic disease that affects dairy cows and milkers. Some chemical disinfectants have been used on farms affected by BV to disinfect cow teats and milkers' hands. To date, there is no information about the efficacy of disinfectants against VACV. Therefore, this study aimed to assess the virucidal activity of some active disinfectants commonly used in the field. Sodium hypochlorite, quaternary ammonium combined with chlorhexidine, and quaternary ammonium combined with glutaraldehyde were effective in inactivating the virus at all concentrations tested. Iodine and quaternary ammonium as the only active component were partially effective. The presence of bovine feces as organic matter and light decreased the effectiveness of sodium hypochlorite. These results show that an appropriated disinfection and asepsis of teats and hands may be helpful in the control and prevention of BV and other infections with VACV.
牛痘病毒（VACV）是牛痘（BV）的病原体，BV 是一种新兴的人畜共患病，会影响奶牛和挤奶工。一些化学消毒剂已在受 BV 影响的农场中用于给奶牛的乳头和挤奶工的手部消毒。迄今为止，尚无关于消毒剂对 VACV 的功效的信息。因此，本研究旨在评估一些在该领域常用的有效消毒剂的病毒杀灭活性。次氯酸钠、季铵盐与洗必泰、季铵盐与戊二醛在所有测试浓度下均有效灭活病毒。碘和季铵盐作为唯一的有效成分部分有效。牛粪便等有机物和光照会降低次氯酸钠的有效性。这些结果表明，适当的乳头和手部消毒和无菌操作可能有助于控制和预防 BV 和其他 VACV 感染。
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