Molecular Epidemiology Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Sep;28(9):1220-3. doi: 10.1080/19440049.2011.584070. Epub 2011 Jul 20.
Deoxynivalenol (DON) is a trichothecene mycotoxin found on wheat, maize and barley. In ecological surveys in China, DON and other trichothecenes have been implicated in acute poisoning episodes and linked with the incidence of esophageal cancer. In order to better understand exposure patterns, this pilot survey provided a combined measure of urinary un-metabolised or free DON (fD) and its glucuronide metabolite (DG) in a subset of 60 samples taken from the Shanghai Women's Health Study cohort, China. Samples were collected in 1997/1998 from women age 40-70 years. Urinary fD+DG combined was detected in 58/60 (96.7%) samples (mean 5.9 ng DON/mg creatinine; range nd-30.5); a similar frequency, and a mean level approximately half, of that previously observed for women in the UK. Wheat consumption was approximately 25% of that consumed by western diets; thus DON contamination of wheat may be higher in Shanghai than the UK. The de-epoxy metabolite of DON, a detoxification product observed in animals, was not detected, suggesting that humans may be particularly sensitive to DON due to a more restricted detoxification capacity.
脱氧雪腐镰刀菌烯醇（DON）是一种在小麦、玉米和大麦中发现的单端孢霉烯族毒素。在中国的生态调查中，DON 和其他单端孢霉烯族毒素与急性中毒事件有关，并与食管癌的发病率有关。为了更好地了解暴露模式，本试点调查在中国上海妇女健康研究队列的 60 个样本中，提供了尿中未代谢或游离 DON（fD）及其葡萄糖醛酸代谢物（DG）的联合测量。样本于 1997/1998 年采集自年龄在 40-70 岁的女性。在 60 个样本中的 58 个（96.7%）中检测到尿 fD+DG 联合（5.9ng DON/mg 肌酐；范围 nd-30.5）；与英国女性的观察结果相似，频率相似，但平均水平约为一半。小麦的摄入量约为西方饮食的 25%；因此，上海的小麦污染可能比英国更高。DON 的去环氧代谢物是动物体内观察到的一种解毒产物，未被检测到，这表明人类由于解毒能力更受限制，可能对 DON 特别敏感。
