Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, California 92697, USA.
Learn Mem. 2011 Aug 18;18(9):565-73. doi: 10.1101/lm.2197211. Print 2011 Sep.
Prior research has demonstrated that the neural correlates of successful encoding ("subsequent memory effects") partially overlap with neural regions selectively engaged by the on-line demands of the study task. The primary goal of the present experiment was to determine whether this overlap is associated solely with encoding processes supporting later recollection, or whether overlapping subsequent memory and study condition effects are also evident when later memory is familiarity-based. Subjects (N = 17) underwent fMRI scanning while studying a series of visually and auditorily presented words. Memory for the words was subsequently tested with a modified Remember/Know procedure. Auditorily selective subsequent familiarity effects were evident in bilateral temporal regions that also responded preferentially to auditory items. Although other interpretations are possible, these findings suggest that overlap between study condition-selective subsequent memory effects and regions selectively sensitive to study demands is not uniquely associated with later recollection. In addition, modality-independent subsequent memory effects were identified in several cortical regions. In every case, the effects were greatest for later recollected items, and smaller for items later recognized on the basis of familiarity. The implications of this quantitative dissociation for dual-process models of recognition memory are discussed.
先前的研究表明，成功编码的神经相关性（“后续记忆效应”）部分与在线研究任务需求选择性激活的神经区域重叠。本实验的主要目的是确定这种重叠是否仅与支持后续回忆的编码过程有关，或者当后续记忆是基于熟悉度时，重叠的后续记忆和研究条件效应是否也明显。受试者（N=17）在进行 fMRI 扫描时，学习了一系列视觉和听觉呈现的单词。随后，通过修改的记得/知道程序测试了对单词的记忆。在双侧颞区出现了听觉选择性的后续熟悉效应，这些区域也对听觉项目有优先反应。虽然还有其他解释，但这些发现表明，研究条件选择性后续记忆效应与对研究需求敏感的区域之间的重叠并不完全与后续回忆相关。此外，还在几个皮质区域中确定了与模态无关的后续记忆效应。在每种情况下，对于后续回忆的项目，效果最大，而对于基于熟悉度后续识别的项目，效果较小。这种定量分离对识别记忆的双过程模型的影响将在文中进行讨论。
