环境微生物菌群是临床相关金属β-内酰胺酶传播的天然储库。
Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases.
机构信息
Área de Microbiología, Universidad de las Islas Baleares, Palma de Mallorca, Spain.
出版信息
Antimicrob Agents Chemother. 2011 Nov;55(11):5376-9. doi: 10.1128/AAC.00716-11. Epub 2011 Aug 22.
Abstract
A total of 10 metallo-β-lactamase-producing isolates of six different species, including Brevundimonas diminuta (n = 3), Rhizobium radiobacter (n = 2), Pseudomonas monteilii (n = 1), Pseudomonas aeruginosa (n = 2), Ochrobactrum anthropi (n = 1), and Enterobacter ludwigii (n = 1), were detected in the sewage water of a hospital. The presence of bla(VIM-13) associated with a Tn1721-class 1 integron structure was detected in all but one of the isolates (E. ludwigii, which produced VIM-2), and in two of them (R. radiobacter), this structure was located on a plasmid, suggesting that environmental bacteria represent a reservoir for the dissemination of clinically relevant metallo-β-lactamase genes.
摘要
在一家医院的污水中总共检测到了 10 株产金属β-内酰胺酶的分离株，分别属于 6 个不同的种，包括苍白杆菌（Brevundimonas diminuta，n = 3）、罗尔斯通氏菌（Rhizobium radiobacter，n = 2）、栖稻假单胞菌（Pseudomonas monteilii，n = 1）、铜绿假单胞菌（Pseudomonas aeruginosa，n = 2）、人源寡养单胞菌（Ochrobactrum anthropi，n = 1）和爱德华氏菌（Enterobacter ludwigii，n = 1）。除了一株（产 VIM-2 的爱德华氏菌）之外，所有分离株均携带 bla(VIM-13)，与 Tn1721 类 1 整合子结构相关，其中两株（罗尔斯通氏菌）的该结构位于质粒上，这表明环境细菌是临床相关金属β-内酰胺酶基因传播的储库。
相似文献
1
Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases.
Antimicrob Agents Chemother. 2011 Nov;55(11):5376-9. doi: 10.1128/AAC.00716-11. Epub 2011 Aug 22.
2
bla(VIM-2) cassette-containing novel integrons in metallo-beta-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital.
Antimicrob Agents Chemother. 2002 Apr;46(4):1053-8. doi: 10.1128/AAC.46.4.1053-1058.2002.
3
Multiniche screening reveals the clinically relevant metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa far from the hospital setting: an ongoing dispersion process?
Appl Environ Microbiol. 2006 May;72(5):3743-5. doi: 10.1128/AEM.72.5.3743-3745.2006.
4
Metallo-beta-lactamase-producing Pseudomonas putida as a reservoir of multidrug resistance elements that can be transferred to successful Pseudomonas aeruginosa clones.
J Antimicrob Chemother. 2010 Mar;65(3):474-8. doi: 10.1093/jac/dkp491. Epub 2010 Jan 12.
5
Nosocomial spread of Pseudomonas aeruginosa isolates expressing the metallo-beta-lactamase VIM-2 in a hematology unit of a French hospital.
Microb Drug Resist. 2005 Fall;11(3):254-9. doi: 10.1089/mdr.2005.11.254.
6
Molecular epidemiology of acquired-metallo-beta-lactamase-producing bacteria in Poland.
Antimicrob Agents Chemother. 2006 Mar;50(3):880-6. doi: 10.1128/AAC.50.3.880-886.2006.
7
Characterization of acquired beta-lactamases and their genetic support in multidrug-resistant Pseudomonas aeruginosa isolates in Taiwan: the prevalence of unusual integrons.
J Antimicrob Chemother. 2006 Sep;58(3):530-6. doi: 10.1093/jac/dkl266. Epub 2006 Jul 1.
8
Analysis of a novel class 1 integron containing metallo-beta-lactamase gene VIM-2 in Pseudomonas aeruginosa.
J Microbiol. 2009 Dec;47(6):753-9. doi: 10.1007/s12275-008-0272-2. Epub 2010 Feb 4.
9
Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.
Antimicrob Agents Chemother. 2009 Apr;53(4):1325-30. doi: 10.1128/AAC.01230-08. Epub 2009 Jan 21.
10
[VIM-2 metallo-ß-lactamase gen detection in a class 1 integron associated to bla(CTX-M-2) in a Pseudomonas aeruginosa clinical isolate in Uruguay: first communication].
Rev Argent Microbiol. 2011 Jul-Sep;43(3):198-202. doi: 10.1590/S0325-75412011000300004.
引用本文的文献
1
A Review of the Diagnostic Approaches for the Detection of Antimicrobial Resistance, Including the Role of Biosensors in Detecting Carbapenem Resistance Genes.
Genes (Basel). 2025 Jun 30;16(7):794. doi: 10.3390/genes16070794.
2
Yearlong analysis of bacterial diversity in hospital sink drains: culturomics, antibiotic resistance and implications for infection control.
Front Microbiol. 2025 Feb 14;15:1501170. doi: 10.3389/fmicb.2024.1501170. eCollection 2024.
3
spp. infection in immunocompromised children: Two case reports.
Germs. 2023 Mar 31;13(1):72-79. doi: 10.18683/germs.2023.1369. eCollection 2023 Mar.
4
Insights into Carbapenem Resistance in Species: Current Status and Future Perspectives.
Int J Mol Sci. 2022 Oct 18;23(20):12486. doi: 10.3390/ijms232012486.
5
Antibiotic Resistance in Pseudomonas.
Adv Exp Med Biol. 2022;1386:117-143. doi: 10.1007/978-3-031-08491-1_5.
6
Genomic Epidemiology of MBL-Producing Pseudomonas putida Group Isolates in Poland.
Infect Dis Ther. 2022 Aug;11(4):1725-1740. doi: 10.1007/s40121-022-00659-z. Epub 2022 Jun 10.
7
Comprehensive Genomic Survey of Antimicrobial-Resistance Bacteria in the Sewage Tank Replacement with Hospital Relocation.
Infect Drug Resist. 2021 Dec 20;14:5563-5574. doi: 10.2147/IDR.S336418. eCollection 2021.
8
Carbapenem Resistance among Marine Bacteria-An Emerging Threat to the Global Health Sector.
Microorganisms. 2021 Oct 14;9(10):2147. doi: 10.3390/microorganisms9102147.
9
Emergence and Genetic Characterization of Plasmid-Encoded VIM-2-Producing with Novel Integron In Isolated from Cerebrospinal Fluid.
Infect Drug Resist. 2021 Aug 24;14:3415-3424. doi: 10.2147/IDR.S320294. eCollection 2021.
10
Klebsiella oxytoca and Emerging Nosocomial Infections.
Curr Microbiol. 2021 Apr;78(4):1115-1123. doi: 10.1007/s00284-021-02402-2. Epub 2021 Mar 3.
本文引用的文献
1
Metallo-beta-lactamase-producing Pseudomonas putida as a reservoir of multidrug resistance elements that can be transferred to successful Pseudomonas aeruginosa clones.
J Antimicrob Chemother. 2010 Mar;65(3):474-8. doi: 10.1093/jac/dkp491. Epub 2010 Jan 12.
2
Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.
PLoS Pathog. 2009 Mar;5(3):e1000353. doi: 10.1371/journal.ppat.1000353. Epub 2009 Mar 27.
3
Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.
Antimicrob Agents Chemother. 2008 Oct;52(10):3589-96. doi: 10.1128/AAC.00465-08. Epub 2008 Jul 21.
4
Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.
Antimicrob Agents Chemother. 2007 Dec;51(12):4329-35. doi: 10.1128/AAC.00810-07. Epub 2007 Oct 15.
5
Multiniche screening reveals the clinically relevant metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa far from the hospital setting: an ongoing dispersion process?
Appl Environ Microbiol. 2006 May;72(5):3743-5. doi: 10.1128/AEM.72.5.3743-3745.2006.
6
New selective media for enumeration and recovery of fluorescent pseudomonads from various habitats.
Appl Environ Microbiol. 1985 Jan;49(1):28-32. doi: 10.1128/aem.49.1.28-32.1985.
7
First isolation of blaVIM-2 in an environmental isolate of Pseudomonas pseudoalcaligenes.
Antimicrob Agents Chemother. 2005 May;49(5):2140-1. doi: 10.1128/AAC.49.5.2140-2141.2005.
8
Metallo-beta-lactamases: the quiet before the storm?
Clin Microbiol Rev. 2005 Apr;18(2):306-25. doi: 10.1128/CMR.18.2.306-325.2005.
9
Two simple media for the demonstration of pyocyanin and fluorescin.
J Lab Clin Med. 1954 Aug;44(2):301-7.
10
Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii.
Antimicrob Agents Chemother. 2003 Jan;47(1):268-73. doi: 10.1128/AAC.47.1.268-273.2003.
Zotero 插件