环境微生物菌群是临床相关金属β-内酰胺酶传播的天然储库。
Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases.
机构信息
Área de Microbiología, Universidad de las Islas Baleares, Palma de Mallorca, Spain.
出版信息
Antimicrob Agents Chemother. 2011 Nov;55(11):5376-9. doi: 10.1128/AAC.00716-11. Epub 2011 Aug 22.
Abstract
A total of 10 metallo-β-lactamase-producing isolates of six different species, including Brevundimonas diminuta (n = 3), Rhizobium radiobacter (n = 2), Pseudomonas monteilii (n = 1), Pseudomonas aeruginosa (n = 2), Ochrobactrum anthropi (n = 1), and Enterobacter ludwigii (n = 1), were detected in the sewage water of a hospital. The presence of bla(VIM-13) associated with a Tn1721-class 1 integron structure was detected in all but one of the isolates (E. ludwigii, which produced VIM-2), and in two of them (R. radiobacter), this structure was located on a plasmid, suggesting that environmental bacteria represent a reservoir for the dissemination of clinically relevant metallo-β-lactamase genes.
摘要
在一家医院的污水中总共检测到了 10 株产金属β-内酰胺酶的分离株，分别属于 6 个不同的种，包括苍白杆菌（Brevundimonas diminuta，n = 3）、罗尔斯通氏菌（Rhizobium radiobacter，n = 2）、栖稻假单胞菌（Pseudomonas monteilii，n = 1）、铜绿假单胞菌（Pseudomonas aeruginosa，n = 2）、人源寡养单胞菌（Ochrobactrum anthropi，n = 1）和爱德华氏菌（Enterobacter ludwigii，n = 1）。除了一株（产 VIM-2 的爱德华氏菌）之外，所有分离株均携带 bla(VIM-13)，与 Tn1721 类 1 整合子结构相关，其中两株（罗尔斯通氏菌）的该结构位于质粒上，这表明环境细菌是临床相关金属β-内酰胺酶基因传播的储库。
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