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Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases.环境微生物菌群是临床相关金属β-内酰胺酶传播的天然储库。
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2
bla(VIM-2) cassette-containing novel integrons in metallo-beta-lactamase-producing Pseudomonas aeruginosa and Pseudomonas putida isolates disseminated in a Korean hospital.在一家韩国医院传播的产金属β-内酰胺酶的铜绿假单胞菌和恶臭假单胞菌分离株中含有bla(VIM-2) 盒的新型整合子
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Multiniche screening reveals the clinically relevant metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa far from the hospital setting: an ongoing dispersion process?多重生态位筛选揭示了在远离医院环境的铜绿假单胞菌中存在具有临床相关性的金属β-内酰胺酶VIM-2：这是一个正在进行的传播过程吗？
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4
Metallo-beta-lactamase-producing Pseudomonas putida as a reservoir of multidrug resistance elements that can be transferred to successful Pseudomonas aeruginosa clones.产金属β-内酰胺酶的铜绿假单胞菌作为多药耐药元件的储库，这些耐药元件可以转移到成功的铜绿假单胞菌克隆中。
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Molecular epidemiology of outbreak-related pseudomonas aeruginosa strains carrying the novel variant blaVIM-17 metallo-beta-lactamase gene.携带新型blaVIM-17金属β-内酰胺酶基因的与暴发相关的铜绿假单胞菌菌株的分子流行病学
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[VIM-2 metallo-ß-lactamase gen detection in a class 1 integron associated to bla(CTX-M-2) in a Pseudomonas aeruginosa clinical isolate in Uruguay: first communication].[乌拉圭一株铜绿假单胞菌临床分离株中与bla(CTX-M-2)相关的1类整合子内VIM-2金属β-内酰胺酶基因检测：首次报道]
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本文引用的文献

1
Metallo-beta-lactamase-producing Pseudomonas putida as a reservoir of multidrug resistance elements that can be transferred to successful Pseudomonas aeruginosa clones.产金属β-内酰胺酶的铜绿假单胞菌作为多药耐药元件的储库，这些耐药元件可以转移到成功的铜绿假单胞菌克隆中。
J Antimicrob Chemother. 2010 Mar;65(3):474-8. doi: 10.1093/jac/dkp491. Epub 2010 Jan 12.
2
Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.由非必需青霉素结合蛋白失活引发的β-内酰胺抗性反应。
PLoS Pathog. 2009 Mar;5(3):e1000353. doi: 10.1371/journal.ppat.1000353. Epub 2009 Mar 27.
3
Characterization of the new metallo-beta-lactamase VIM-13 and its integron-borne gene from a Pseudomonas aeruginosa clinical isolate in Spain.西班牙一株铜绿假单胞菌临床分离株中新金属β-内酰胺酶VIM-13及其整合子携带基因的特征分析
Antimicrob Agents Chemother. 2008 Oct;52(10):3589-96. doi: 10.1128/AAC.00465-08. Epub 2008 Jul 21.
4
Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.西班牙医院分离的铜绿假单胞菌中碳青霉烯类耐药的分子流行病学及机制
Antimicrob Agents Chemother. 2007 Dec;51(12):4329-35. doi: 10.1128/AAC.00810-07. Epub 2007 Oct 15.
5
Multiniche screening reveals the clinically relevant metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa far from the hospital setting: an ongoing dispersion process?多重生态位筛选揭示了在远离医院环境的铜绿假单胞菌中存在具有临床相关性的金属β-内酰胺酶VIM-2：这是一个正在进行的传播过程吗？
Appl Environ Microbiol. 2006 May;72(5):3743-5. doi: 10.1128/AEM.72.5.3743-3745.2006.
6
New selective media for enumeration and recovery of fluorescent pseudomonads from various habitats.新型选择性培养基用于从各种生境中计数和回收荧光假单胞菌。
Appl Environ Microbiol. 1985 Jan;49(1):28-32. doi: 10.1128/aem.49.1.28-32.1985.
7
First isolation of blaVIM-2 in an environmental isolate of Pseudomonas pseudoalcaligenes.首次在假产碱假单胞菌的环境分离株中分离出blaVIM-2。
Antimicrob Agents Chemother. 2005 May;49(5):2140-1. doi: 10.1128/AAC.49.5.2140-2141.2005.
8
Metallo-beta-lactamases: the quiet before the storm?金属β-内酰胺酶：暴风雨前的宁静？
Clin Microbiol Rev. 2005 Apr;18(2):306-25. doi: 10.1128/CMR.18.2.306-325.2005.
9
Two simple media for the demonstration of pyocyanin and fluorescin.两种用于展示绿脓菌素和荧光素的简单培养基。
J Lab Clin Med. 1954 Aug;44(2):301-7.
10
Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii.鲍曼不动杆菌染色体编码的碳青霉烯水解型苯唑西林酶OXA-40的遗传与功能分析
Antimicrob Agents Chemother. 2003 Jan;47(1):268-73. doi: 10.1128/AAC.47.1.268-273.2003.

环境微生物菌群是临床相关金属β-内酰胺酶传播的天然储库。

Environmental microbiota represents a natural reservoir for dissemination of clinically relevant metallo-beta-lactamases.

机构信息

Área de Microbiología, Universidad de las Islas Baleares, Palma de Mallorca, Spain.

出版信息

Antimicrob Agents Chemother. 2011 Nov;55(11):5376-9. doi: 10.1128/AAC.00716-11. Epub 2011 Aug 22.

DOI:10.1128/AAC.00716-11
PMID:21859934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3195059/
Abstract

A total of 10 metallo-β-lactamase-producing isolates of six different species, including Brevundimonas diminuta (n = 3), Rhizobium radiobacter (n = 2), Pseudomonas monteilii (n = 1), Pseudomonas aeruginosa (n = 2), Ochrobactrum anthropi (n = 1), and Enterobacter ludwigii (n = 1), were detected in the sewage water of a hospital. The presence of bla(VIM-13) associated with a Tn1721-class 1 integron structure was detected in all but one of the isolates (E. ludwigii, which produced VIM-2), and in two of them (R. radiobacter), this structure was located on a plasmid, suggesting that environmental bacteria represent a reservoir for the dissemination of clinically relevant metallo-β-lactamase genes.

摘要

在一家医院的污水中总共检测到了 10 株产金属β-内酰胺酶的分离株，分别属于 6 个不同的种，包括苍白杆菌（Brevundimonas diminuta，n = 3）、罗尔斯通氏菌（Rhizobium radiobacter，n = 2）、栖稻假单胞菌（Pseudomonas monteilii，n = 1）、铜绿假单胞菌（Pseudomonas aeruginosa，n = 2）、人源寡养单胞菌（Ochrobactrum anthropi，n = 1）和爱德华氏菌（Enterobacter ludwigii，n = 1）。除了一株（产 VIM-2 的爱德华氏菌）之外，所有分离株均携带 bla(VIM-13)，与 Tn1721 类 1 整合子结构相关，其中两株（罗尔斯通氏菌）的该结构位于质粒上，这表明环境细菌是临床相关金属β-内酰胺酶基因传播的储库。