Xie Baogang, Waters Michael J, Schirra Horst Joachim
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
J Biomed Biotechnol. 2012;2012:805683. doi: 10.1155/2012/805683. Epub 2012 May 16.
Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Metabolomics is an emerging analytical technique for systemic determination of metabolite profiles, which is useful for understanding the biochemical changes in obesity or related diseases both in individual organs and at the organism level. Increasingly, this technology has been applied to the study of obesity, complementing transcriptomics and/or proteomics analyses. Indeed, the alterations of metabolites in biofluids/tissues are direct indicators of variations in physiology or pathology. In this paper, we will examine the obesity-related alterations in significant metabolites that have been identified by metabolomics as well as their metabolic pathway associations. Issues concerning the screening of biologically significant metabolites related to obesity will also be discussed.
肥胖是一个严重的健康问题，会增加患几种常见疾病的风险，包括糖尿病、心血管疾病和癌症。代谢组学是一种新兴的分析技术，用于系统地测定代谢物谱，有助于在个体器官和生物体水平上理解肥胖或相关疾病中的生化变化。这项技术越来越多地应用于肥胖研究，对转录组学和/或蛋白质组学分析起到补充作用。事实上，生物流体/组织中代谢物的变化是生理或病理变化的直接指标。在本文中，我们将研究代谢组学鉴定出的与肥胖相关的重要代谢物变化及其代谢途径关联。还将讨论与肥胖相关的具有生物学意义的代谢物筛选问题。
