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学龄前儿童肾结石(包括三聚氰胺污染奶粉所致结石)的微创经皮肾镜取石术

Minimally invasive percutaneous nephrolithotomy in preschool age children with kidney calculi (including stones induced by melamine-contaminated milk powder).

作者信息

Yan Xiang, Al-Hayek Samih, Gan Weidong, Zhu Wei, Li Xiaogong, Guo Hongqian

机构信息

Department of Urology, Affiliated Drum Tower Hospital, Nanjing University, Nanjing, 210008, China.

出版信息

Pediatr Surg Int. 2012 Oct;28(10):1021-4. doi: 10.1007/s00383-012-3112-8. Epub 2012 Jun 23.

DOI:10.1007/s00383-012-3112-8
PMID:22729672
Abstract

PURPOSE

This study was undertaken to assess the safety and efficacy of minimally invasive percutaneous nephrolithotomy (mini-PCNL) using ureteroscope and pneumatic intracorporeal lithotripsy in preschool age children with kidney calculi.

METHODS

We studied 27 renal units in 20 patients of preschool age (≤ 6 years) who underwent mini-PCNL at our institute. The mean age was 42.6 months (range 14-68 months). The average stone burden was 1.85 cm (range 0.9-2.8 cm). Eight patients aged 14 to 58 months had been exposed to melamine-tainted powdered formula. The mini-PCNL was performed with an X-ray-guided peripheral puncture. Minimal tract dilatation was undertaken to fit a 14-16 Fr peel-away sheath. Ureteroscope and pneumatic intracorporeal lithotripsy were used to fragment the stones.

RESULTS

Complete clearance was achieved in 23 renal units (85.2 %) with mini-PCNL monotherapy. This has increased to 92.6 % after adjunctive ESWL. The average fall in hemoglobin was 1.28 g/dL. None of the patients required blood transfusion. The median length of hospital stay was 8.2 days. Patients were followed up every 6 months for 2 years. There has been only one recurrence of stone and no long-term complications.

CONCLUSION

Mini-PCNL is a effective treatment for pediatric kidney stones refractory to extracorporeal shock wave lithotripsy, including stones induced by melamine-contaminated milk powder. The "mini-PCNL" technique, which uses ureteroscope and pneumatic intracorporeal lithotripsy, is a safe and feasible modality for treating renal calculi in preschool age children.

摘要

目的

本研究旨在评估使用输尿管镜和气压弹道碎石术的微创经皮肾镜取石术(mini-PCNL)治疗学龄前儿童肾结石的安全性和有效性。

方法

我们研究了在我院接受mini-PCNL的20例学龄前(≤6岁)患者的27个肾单位。平均年龄为42.6个月(范围14 - 68个月)。平均结石负荷为1.85 cm(范围0.9 - 2.8 cm)。8例年龄在14至58个月的患者曾接触过三聚氰胺污染的奶粉。mini-PCNL采用X线引导下的经皮肾穿刺造瘘术,采用最小限度的通道扩张以置入14 - 16 Fr的 Peel-away鞘,使用输尿管镜和气压弹道碎石术将结石击碎。

结果

mini-PCNL单一疗法使23个肾单位(85.2%)实现了结石完全清除。辅助体外冲击波碎石术(ESWL)后,这一比例增至92.6%。血红蛋白平均下降1.28 g/dL。所有患者均无需输血。中位住院时间为8.2天。患者每6个月随访一次,共随访2年。仅出现1例结石复发,无长期并发症发生。

结论

Mini-PCNL是治疗体外冲击波碎石术无效的小儿肾结石的有效方法,包括由三聚氰胺污染奶粉所致的结石。采用输尿管镜和气压弹道碎石术的“mini-PCNL”技术是治疗学龄前儿童肾结石的一种安全可行的方式。

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