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1
Lymphocyte transformation induced by autologous cells. VIII. Impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis.自体细胞诱导的淋巴细胞转化。VIII. 急性传染性单核细胞增多症患者自体混合淋巴细胞反应受损。
J Exp Med. 1979 Dec 1;150(6):1448-55. doi: 10.1084/jem.150.6.1448.
2
Characteristic T cell dysfunction in patients with chronic active Epstein-Barr virus infection (chronic infectious mononucleosis).慢性活动性EB病毒感染（慢性传染性单核细胞增多症）患者典型的T细胞功能障碍。
J Immunol. 1985 May;134(5):3082-8.
3
Lymphocyte subpopulations and reactivity during and after infectious mononucleosis.
Med Biol. 1983;61(4):208-13.
4
The MLC response of patients with infectious mononucleosis to Epstein-Barr virus-transformed cells.传染性单核细胞增多症患者对爱泼斯坦-巴尔病毒转化细胞的混合淋巴细胞培养反应。
Arch Immunol Ther Exp (Warsz). 1983;31(6):871-8.
5
Letter: Epstein-Barr virus and infectious mononucleosis.信件：爱泼斯坦-巴尔病毒与传染性单核细胞增多症。
Lancet. 1973 Nov 17;2(7838):1152. doi: 10.1016/s0140-6736(73)90960-4.
6
Depression of cell-mediated immunity during acute infectious mononucleosis.急性传染性单核细胞增多症期间细胞介导免疫的抑制。
N Engl J Med. 1974 Nov 28;291(22):1149-53. doi: 10.1056/NEJM197411282912202.
7
Cell-mediated immunity to Epstein-Barr-virus-transformed lymphoblastoid cells in acute infectious mononucleosis.急性传染性单核细胞增多症中针对爱泼斯坦-巴尔病毒转化的淋巴母细胞的细胞介导免疫。
N Engl J Med. 1975 Dec 4;293(23):1159-63. doi: 10.1056/NEJM197512042932301.
8
Lymphocyte subpopulations in man: suppression of PWM-induced B-cell proliferation by infectious mononucleosis T cells.人类淋巴细胞亚群：传染性单核细胞增多症T细胞对PWM诱导的B细胞增殖的抑制作用。
Scand J Immunol. 1979;10(3):251-5. doi: 10.1111/j.1365-3083.1979.tb01347.x.
9
Blastogenic response of purified human T-lymphocyte populations to Epstein-Barr virus (EBV).纯化的人T淋巴细胞群体对爱泼斯坦-巴尔病毒（EBV）的增殖反应。
Clin Exp Immunol. 1977 Dec;30(3):347-53.
10
Activation of suppressor T cells during Epstein-Barr-virus-induced infectious mononucleosis.爱泼斯坦-巴尔病毒引起的传染性单核细胞增多症期间抑制性T细胞的激活
N Engl J Med. 1979 Nov 22;301(21):1133-7. doi: 10.1056/NEJM197911223012101.

引用本文的文献

1
Studies of proliferative responses by long-term-cryopreserved peripheral blood mononuclear cells to bacterial components associated with periodontitis.长期冷冻保存的外周血单个核细胞对与牙周炎相关细菌成分的增殖反应研究。
Clin Diagn Lab Immunol. 1996 Nov;3(6):710-6. doi: 10.1128/cdli.3.6.710-716.1996.
2
Monoclonal anti-human T-lymphocyte antibodies: enumeration and characterization of T-cell subsets.单克隆抗人T淋巴细胞抗体：T细胞亚群的计数与特征分析
Immunology. 1981 Jan;42(1):157-64.
3
T-cell macrophage subset interactions and decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.干燥综合征中T细胞-巨噬细胞亚群相互作用及自体混合淋巴细胞反应降低
Rheumatol Int. 1983;3(1):13-7. doi: 10.1007/BF00541226.
4
Generation of suppressor cells in the autologous mixed lymphocyte reaction.自体混合淋巴细胞反应中抑制细胞的产生。
Clin Exp Immunol. 1981 Oct;46(1):185-95.
5
Factors influencing the autologous mixed lymphocyte reaction in rats: effect of xenogeneic serum protein.影响大鼠自体混合淋巴细胞反应的因素：异种血清蛋白的作用。
Immunology. 1981 Nov;44(3):499-507.
6
Lymphocyte transformation induced by autologous cells. XI. The effect of age on the autologous mixed lymphocyte reaction.自体细胞诱导的淋巴细胞转化。十一、年龄对自体混合淋巴细胞反应的影响。
Immunology. 1981 Oct;44(2):431-8.
7
Decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.干燥综合征中自体混合淋巴细胞反应降低。
J Clin Invest. 1980 Nov;66(5):928-33. doi: 10.1172/JCI109960.
8
Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation.类风湿关节炎淋巴细胞导致爱泼斯坦-巴尔病毒诱导的B细胞增殖调节受损的缺陷分析。I. 自体刺激后γ干扰素产生减少。
J Exp Med. 1983 Jan 1;157(1):173-88. doi: 10.1084/jem.157.1.173.
9
Activation of immune regulatory circuits among OKT4+ cells by autologous mixed lymphocyte reactions.通过自体混合淋巴细胞反应激活OKT4 +细胞间的免疫调节回路。
Clin Exp Immunol. 1984 May;56(2):390-8.
10
Impaired autologous mixed lymphocyte reaction with normal concanavalin A-induced suppression in adult polymyositis/dermatomyositis.成人多发性肌炎/皮肌炎中自体混合淋巴细胞反应受损，伴正常刀豆蛋白A诱导的抑制作用。
Clin Exp Immunol. 1983 Jul;53(1):67-75.

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DEPRESSION OF TUBERCULIN SENSITIVITY FOLLOWING MEASLES VACCINATION.麻疹疫苗接种后结核菌素敏感性降低
Am Rev Respir Dis. 1964 Oct;90:607-11. doi: 10.1164/arrd.1964.90.4.607.
2
The effect of certain infectious diseases on tuberculin allergy.某些传染病对结核菌素过敏的影响。
Tubercle. 1953 Feb;34(2):34-41. doi: 10.1016/s0041-3879(53)80013-9.
3
Depression of cell-mediated immunity during acute infectious mononucleosis.急性传染性单核细胞增多症期间细胞介导免疫的抑制。
N Engl J Med. 1974 Nov 28;291(22):1149-53. doi: 10.1056/NEJM197411282912202.
4
Abnormalities in the mixed leukocyte reaction during infectious mononucleosis.传染性单核细胞增多症期间混合淋巴细胞反应的异常。
J Immunol. 1974 Jun;112(6):2278-81.
5
Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes.人类B淋巴细胞和T淋巴细胞的表面标志物。II. B淋巴细胞上爱泼斯坦-巴尔病毒受体的存在
J Exp Med. 1973 Dec 1;138(6):1365-78. doi: 10.1084/jem.138.6.1365.
6
Cell-mediated immunity to Varicella-Zoster antigen in acute Herpes zoster (shingles).急性带状疱疹（带状疱疹）中针对水痘-带状疱疹抗原的细胞介导免疫
Clin Exp Immunol. 1973 Jun;14(2):181-5.
7
Evidence for membrane antigen(s) specific for human B lymphoblasts.针对人类B淋巴母细胞的膜抗原证据。
Clin Exp Immunol. 1973 May;14(1):91-6.
8
Tuberculin anergy and infectious mononucleosis.结核菌素无反应性与传染性单核细胞增多症。
Lancet. 1973 Jul 14;2(7820):74. doi: 10.1016/s0140-6736(73)93265-0.
9
Cell-mediated immunity in rubella assayed by cytotoxicity of supernatants from rubella virus-stimulated human lymphocyte cultures.通过风疹病毒刺激的人淋巴细胞培养上清液的细胞毒性检测风疹中的细胞介导免疫。
Clin Exp Immunol. 1975 Jan;19(1):33-43.
10
Complement, lymphocytotoxins and immune complexes in infectious mononucleosis: serial studies in uncomplicated cases.传染性单核细胞增多症中的补体、淋巴细胞毒素及免疫复合物：非复杂性病例的系列研究
Clin Exp Immunol. 1978 Nov;34(2):241-7.

自体细胞诱导的淋巴细胞转化。VIII. 急性传染性单核细胞增多症患者自体混合淋巴细胞反应受损。

Lymphocyte transformation induced by autologous cells. VIII. Impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis.

作者信息

Moody C E, Casazza B A, Christenson W N, Weksler M E

出版信息

J Exp Med. 1979 Dec 1;150(6):1448-55. doi: 10.1084/jem.150.6.1448.

DOI:10.1084/jem.150.6.1448
PMID:229189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185737/
Abstract

The autologous mixed lymphocyte reaction (MLR) is severely impaired in patients with acute infectious mononucleosis. Reactivity returned during the course of convalescence. The allogeneic MLR was not impaired in these patients. B cells from patients with infectious mononucleosis do not stimulate autologous T-cell proliferation, and this observation appears to explain the cellular basis of the impaired autologous MLR in infection. Two explanations for the B-cell defect were considered: (a) the influence of serum factors on B-cell function and (b) the effect of Epstein-Barr virus infection.

摘要

急性传染性单核细胞增多症患者的自体混合淋巴细胞反应（MLR）严重受损。恢复期反应性恢复。这些患者的同种异体MLR未受损。传染性单核细胞增多症患者的B细胞不会刺激自体T细胞增殖，这一观察结果似乎解释了感染中自体MLR受损的细胞基础。对B细胞缺陷有两种解释：（a）血清因子对B细胞功能的影响和（b）爱泼斯坦-巴尔病毒感染的影响。