自体细胞诱导的淋巴细胞转化。VIII. 急性传染性单核细胞增多症患者自体混合淋巴细胞反应受损。
Lymphocyte transformation induced by autologous cells. VIII. Impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis.
作者信息
Moody C E, Casazza B A, Christenson W N, Weksler M E
出版信息
J Exp Med. 1979 Dec 1;150(6):1448-55. doi: 10.1084/jem.150.6.1448.
Abstract
The autologous mixed lymphocyte reaction (MLR) is severely impaired in patients with acute infectious mononucleosis. Reactivity returned during the course of convalescence. The allogeneic MLR was not impaired in these patients. B cells from patients with infectious mononucleosis do not stimulate autologous T-cell proliferation, and this observation appears to explain the cellular basis of the impaired autologous MLR in infection. Two explanations for the B-cell defect were considered: (a) the influence of serum factors on B-cell function and (b) the effect of Epstein-Barr virus infection.
摘要
急性传染性单核细胞增多症患者的自体混合淋巴细胞反应（MLR）严重受损。恢复期反应性恢复。这些患者的同种异体MLR未受损。传染性单核细胞增多症患者的B细胞不会刺激自体T细胞增殖，这一观察结果似乎解释了感染中自体MLR受损的细胞基础。对B细胞缺陷有两种解释：（a）血清因子对B细胞功能的影响和（b）爱泼斯坦-巴尔病毒感染的影响。
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